A Case of Multiple Myeloma Presenting with Diabetes Insipidus
Journal Title: Sultan Qaboos University Medical Journal - Year 2017, Vol 17, Issue 2
Abstract
Multiple myeloma (MM) can present with involvement of the central nervous system in the form of nerve palsy, plasma cell masses or, rarely, with endocrinological effects due to involvement of the pituitary gland. Usually, in such cases, the disease has a rapid progression and poor prognosis. We report a 52-year-old man who was admitted to the Kolkata Medical College, Kolkata, India, in 2016 with a prolonged low-grade fever and hypernatremia. Shortly afterwards, the patient began to complain of increased urinary frequency and drowsiness. Te hypernatremia was treated with intranasal desmopressin and free water replacement. Serum protein electrophoresis and an immunofxation study revealed an immunoglobulin G-κ monoclonal band. Magnetic resonance imaging of the pituitary gland revealed the absence of a posterior bright spot and spotty infltration of the pituitary fossa. A bone marrow biopsy confrmed a diagnosis of cranial diabetes insipidus due to posterior pituitary MM infltration.
Authors and Affiliations
Rudrajit Paul| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India, Aditya V. Ruia| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India, Asim Saha| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India, Jayati Mondal| Department of Gynaecology, Chittaranjan Seva Sadan Hospital, Kolkata, West Bengal, India, T. J. Sau| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India, Indranil Takur| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India, Kunal Haldar| Department of Medicine, Kolkata Medical College, Kolkata, West Bengal, India
Keywords
Related Articles
- EP ID EP14777
- DOI 10.18295/squmj.2016.17.02.015
- Views 288
- Downloads 20
A Case of Gastric and Duodenal Strongyloidiasis
Strongyloides stercoralis is a nematode parasite which causes a protracted asymptomatic intestinal infection. It is considered a life threatening condition in immunocompromised patients when hyperinfection is associate...
Hepatoblastomas in Oman Unveiling success
Objectives: Primary malignant liver tumours account for more than 1% of all paediatric malignancies, with the most common form being hepatoblastomas (HB). Such malignancies among Arab populations have rarely been addre...
Distribution of Trauma Care Facilities in Oman in Relation to High-Incidence Road Traffc Injury Sites Pilot study
Objectives: Road trafc injuries (RTIs) are considered a major public health problem worldwide. In Oman, high numbers of RTIs and RTI-related deaths are frequently registered. Tis study aimed to evaluate the distributio...
Seizures as an Atypical Feature of Beal’s Syndrome
Congenital contractural arachnodactyly, commonly known as Beal’s syndrome, is an extremely rare genetic disorder caused by mutations in the fbrillin-2 (FBN2) gene located on chromosome 5q23. It is an autosomal domina...
Hypercalcaemia: A portent of sarcoidosis in cystic fibrosis
The coexistence of cystic fibrosis (CF) and sarcoidosis is rare. We report a 22-year-old male cystic fibrosis patient who presented multiple times to the Sultan Qaboos University Hospital, Muscat, Oman, in 2013. He was d...