First Cytogenetic Profle of Omani Patients with de novo Myelodysplastic Syndromes Comparison with data from Asia, Africa, Europe and North and South America
Journal Title: Sultan Qaboos University Medical Journal - Year 2017, Vol 17, Issue 3
Abstract
Clonal cytogenetic abnormalities have been reported among 30–80% of patients with myelodysplastic syndromes (MDS); however, 20–70% of patients with MDS show a normal karyotype that may nevertheless harbour a cryptic genetic alteration. Earlier reports have suggested that the distribution of specifc chromosomal aberrations varies among Western and Asian countries, with geographical and ethnic differences in the frequency of specifc chromosomal aberrations. Tis article compared the cytogenetic data of 36 adult Omani patients with MDS to previously reported data from other populations. Differences were noted between the percentages of clonal aberrations and the median age of Omani subjects at presentation in comparison to individuals of different ethnicities and from various geographical locations. To the best of the authors’ knowledge, this is the frst report to describe the cytogenetic data of patients with MDS from Oman.
Authors and Affiliations
Achandira M. Udayakumar| Departments of Genetics, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman; Department of Malignancy Cytogenetics & Molecular Pathology, Hammersmith Hospital, Imperial College Healthcare National Health Service Trust, London, UK, Nagla Fawaz| Departments of Haematology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Anil Pathare| Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman, Shakila Asraf| Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman, Mohammed Al-Huneini| Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman, Khalil Al-Farsi| Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman, Salam Al-Kindi| Departments of Haematology, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman, Murtadha Al-Khabouri| Department of Haematology, Sultan Qaboos University Hospital, Muscat, Oman
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- EP ID EP14791
- DOI 10.18295/squmj.2017.17.03.005
- Views 304
- Downloads 19
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