FORMULATION DEVELOPMENT AND EVALUATION OF LOPERAMIDE HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
There is an increasing demand for more patient compliant dosage form and a novel method is the development of orally disintegrating tablets which dissolve or disintegrates instantly on the patient tongue or buccal mucosa. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect and make it more cost effective. Loperamide hydrochloride is a drug of choice for diarrhoea. Loperamide hydrochloride has systemic bioavailability too low due to extensive hepatic first pass metabolism. Hence the main objective of the study was to formulate orally disintegrating tablets of Loperamide hydrochloride to achieve a better dissolution rate and further improving the bioavailability of the drug and to get relief from diarrhoea very quickly. Orally disintegrating tablets prepared by direct compression and using super disintegrant crosspovidone were prepared and evaluated for the pre- compression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability,drug content, disintegration time and in-vitro dissolution profile and found satisfactory. Among the 6 groups (f1, f2, f3, f4, f5, f6),formulation f4 emerged as the best formulation and showed rapid dissolution rate i.e. it releases 95% drug in 5 min.
Authors and Affiliations
A Bharathi, K Mohan Guptha, Y Uma Jagannadha Rao
Keywords
Related Articles
- EP ID EP33013
- DOI -
- Views 454
- Downloads 0
The neohydrodynamic theory of dentinal hypersensitivity
The neohydrodynamic theory of dentinal hypersensitivity is to reveal the real mechanism behind the dentinal hypersensitivity. The hydrodynamic theory proposed by Branstrom will support only under pathological condition...
Application of nano materials in pharmacy and agriculture
Nano materials, applications in Pharmacy(Carbon nanotubes, Quantum dots, Dendrimers, Metallic nanoparticles, Polymeric nanoparticles, Liposomes, Polymeric micelles, Polymer drug conjugate and Polyplexes/Lipopolyplexes)...
Evaluation of hypo lipidemic and antioxident properties of methanolic extract of leaves of Tectona grandis linn on Mithionine induced model in Wister albino rats
The Methanolic extract of Tectona grandis leaves was subjected to phytochemical screening to find the chemical constituents present. The extract revealed the presence of carbohydrates, alkaloids, phytosterols, proteins...
Calotropis gigantea (L.) Dryand – A review update
Calotropis gigantea (L.) Dryand (Giant milk weed; family Asclepiadaceae) has been traditionally used in the treatment of bronchitis, asthma, leprosy, eczema and elephantiasis. This review emphasizes on ethnopharmacolog...
RECENT TRENDS IN USAGE OF POLYMERS IN THE FORMULATION OF DERMATOLOGICAL GELS
Topical preparations can be applied directly to an external body surface by spreading, rubbing, and spraying. The topical route of administration has been utilized either to produce local effect for treating skin disor...