FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE

FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE

Journal

Subject and more

  • LCC Subject Category: Medicine
  • Publisher's keywords: Stavudine, floating microballoons, floating drug delivery system
  • Language of fulltext: english
  • Full-text formats available: PDF

AUTHORS

    Felix Sunday Yusuf

EDITORIAL INFORMATION

FULL TEXT

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ABSTRACT

Objective of present study involves preparation and evaluation of floating microballoons of Stavudine. It is a potent antiviral agent, used for treatment of human immunodeficiency virus (HIV) infection. In present study Stavudine is used as a model drug, to increase its residence time in the stomach without contact with the mucosa. The microballoons were prepared by the emulsion solvent diffusion technique using different ratio of polymers (Eudragit S100, Ethyl cellulose and PVP K 30) as carriers. The yield of microballoons was up to 68.32-80.22 %. The cumulative percent drug release after 24 hrs of the Stavudine microballoons was in the range of 53.62 to 87.45 %.

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