ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION

ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION

Journal

Subject and more

  • LCC Subject Category: Medicine
  • Publisher's keywords: Abacavir, nanoparticles, solvent displacement method, zeta
  • Language of fulltext: english
  • Full-text formats available: PDF

AUTHORS

    Felix Sunday Yusuf, Yunus A A, Dingwoke Francis John, Udokwu Japheth Chigbo

EDITORIAL INFORMATION

FULL TEXT

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ABSTRACT

The present study deals with the formulation and evaluation of Abacavir nanoparticles. Abacavir is an anti-retroviral drug; it is used in treatment of AIDS. Abacavir nanoparticles were formulated by solvent displacement method using Eudragit RL-100, chitosan and Poloxamer-188. Nanoparticles were characterized by determining its particle size, drug entrapment efficiency, particle morphological character and in-vitro drug release. Particle size range of nanoparticles was in the range of 121.4-140.6 nm. Zeta potential of formulations was determined, and it was found in range of 16.5-20.45 mv. The in-vitro release of nanoparticles were carried out which exhibited a sustained release of Abacavir from nanoparticles up to 10 hrs. The study concludes that nanoparticles can be a promising drug delivery system for sustained release of Abacavir in terms of increased bioavailability.

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