FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS

FORMULATION AND EVALUATION OF FINASTERIDE SUSTAINED-RELEASE MATRIX TABLETS USING DIFFERENT RATE CONTROLLING POLYMERS

Journal

Subject and more

  • LCC Subject Category: Medicine
  • Publisher's keywords: Sustained release, matrix tablets, wet granulation
  • Language of fulltext: english
  • Full-text formats available: PDF

AUTHORS

    Igwe J. Chibueze, Emenike IV, Oduola A R

EDITORIAL INFORMATION

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ABSTRACT

The aim of the present investigation was to develop oral controlled release matrix tablet formulations of Finasteride with different polymer ratios. Finasteride is chemically considered a synthetic 4-azasteroid drug. The granules were evaluated for angle of repose, bulk density and Compressibility index before being punched as tablets. The tablets were subjected to weight variation test, drug content, hardness, friability, and in vitro release studies. Observations of all formulations for physical characterization had shown that, all of them comply with the specifications of official pharmacopoeias and/or standard references. Different models for kinetic study were applied like zero order, first order, Higuchi, Hixson Crowell and Korsmeyer to study the release pattern and mechanism.

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