IN -VIVO ANTI-DIARRHOEAL ACTIVITY OF METHANOL EXTRACT OF BOMBAX BUONOPOZENSE
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 1
Abstract
Diarrhoeal disease is responsible for mortality and morbidity, especially among children in developing countries causing a major healthcare problem. The purpose of the present study was to evaluate anti-diarrhoeal effects of methanolic extract of whole plant of Bombax buonopozense against castor oil-induced diarrhoea model and small intestine transit model in rats. Small intestinal transit models in rats.the number of droppings and the distance traveled by charcoal in intestine were measured. Loperamide (2.5 mg/kg) was used as standard drug, and it has shown significant reductions in fecal output and frequency of droppings whereas extract at the doses of 200 and 400 mg/kg reduced the castor-oil induced frequency and consistency of diarrhoea. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrhoeal agent.
Authors and Affiliations
Fatima A. Adamude, Moh Kingsley Onyekachi
Keywords
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- EP ID EP36374
- DOI https://doi.org/10.22270/ujpr.v2i1.R1
- Views 320
- Downloads 0
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