SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL IMIDAZOLE BASED COMPOUNDS
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 1
Abstract
Some new imidazole derivatives (3i-xii) were synthesized as per design synthetic protocol scheme. The structures of newly prepared compounds were confirmed by modern analytical technique and elemental analysis. All the synthetic compounds were screened for their antimicrobial activity against bacterial results showed good to remarkable activity. The MIC (minimum inhibitory concentration) values were determined by comparison to ciprofloxacin (anti-bacterial) and fluconazole (anti-fungal) as standard drug. Among them, compound 3iv and 3x exhibited notable antimicrobial activity. These compounds may be used as new template for the searching of potential antimicrobial agents.
Authors and Affiliations
Bipin Kumar Verma, Sunil Kapoor, Umesh Kumar, Savita Pandey, Priti Arya
Keywords
Related Articles
- EP ID EP36378
- DOI https://doi.org/10.22270/ujpr.v2i1.R5
- Views 299
- Downloads 0
A REVIEW OF BREAST CANCER RISK FACTORS
Breast cancer is a commonly diagnosed neoplastic ailment in females particularly near menopause. This ailment signifies a substantial health problem as it has influenced a large number of women. Several risk factors are...
PREVALENCE OF HEPATITIS G VIRUS AMONG PATIENTS WITH CHRONIC LIVER DISEASE AND HEALTHY INDIVIDUALS, SANA'A CITY-YEMEN
Hepatitis G virus (HGV) is a newly discovered and enveloped RNA positive-stranded flavivirus-like particle, which has not yet been proven to have major negative effects on liver. Therefore, it is important to estimate th...
PATTERN OF ANTIMICROBIAL PRESCRIBING AMONG IN-PATIENTS OF A TEACHING HOSPITAL IN YEMEN: A PROSPECTIVE STUDY
The irrational use of antimicrobials leads to a number of consequences in term of cost, drug interactions, hospital stay and bacterial resistance, and a substantial economic burden on health care systems. This study aime...
EPIDEMICITY OF VIBRIO CHOLERA IN SANA’A CITY, YEMEN: PREVALENCE AND POTENTIAL DETERMINANTS
In 2017, a total of 889854 suspected cholera cases with 2578 deaths were reported from Yemen, thus WHO considered these figures to be the worst epidemic of cholera in recent history of humanity. The aims of the study we...
DEVELOPMENT AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF PIOGLITAZONE HYDROCHLORIDE
In present study, different transdermal patches of Pioglitazone hydrochloride were prepared using different polymers and evaluated on many parameters. Locally fabricated Franz diffusion cell was used for the in-vitrorele...