ANTI-HYPERGLYCEMIC AND ANTI-OXIDANT ACTIVITIES OF METHANOL EXTRACT OF GONGRONEMA LATIFOLIUM
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 2
Abstract
Gongronema latifolium (Asclepiadiaceae) is used as bitter spice or flavouring agent in many traditional Nigerian dishes. It is well known for medicinal and nutritional purposes like anti-hyperglycemic, anti-oxidant, antitussive and widely distributed in the southeastern states of Nigeria. Objective of present study was to evaluate the anti-hyperglycemic and anti-oxidant effect of the methanol extract of Gongronema latifolium leaves. The methanol extract of G. latifolium at doses of 250 and 500 mg/kg were studied for anti-hyperglycemic effect in alloxan-induced hyperglycemic rats. The variation in blood glucose level in normal and experimental rats on 0, 7, 14 and 21 days of treatment has also been recorded. Treatment with G. latifolium extract showed signs of recovery as comparable with the standard drug glibenclamide (0.25 mg/kg). The effect of different treatment on body weight of rats was also determined. The antioxidant properties of the extracts as determined by the DPPH free radical scavenging assay. The result showed that G. latifolium extract caused a concentration dependent percentage increase of antioxidant activity. Study concludes that methanol leaf extract of G. latifolium possesses significant anti-hyperglycemic and anti-oxidant activities.
Authors and Affiliations
Edenta Chidi, Nwobodo Ndubuisi Nwobodo, Nweje-Anyalowu Paul C
Keywords
Related Articles
- EP ID EP36384
- DOI https://doi.org/10.22270/ujpr.v2i2.R4
- Views 312
- Downloads 0
FORMULATION AND IN-VITRO EVALUATION OF FLOATING MICROBALLOONS OF STAVUDINE
Objective of present study involves preparation and evaluation of floating microballoons of Stavudine. It is a potent antiviral agent, used for treatment of human immunodeficiency virus (HIV) infection. In present study...
A CROSS-SECTIONAL STUDY ON BENZODIAZIPINE (BZD) ABUSERS OF DHAKA CITY: A SOCIO-PSYCHOLOGICAL CONDITION OF BANGLADESH
Benzodiazepines (BZD) are highly potential drug for abuse among the most frequently prescribed medicine. Different studies say that young-adults are the vulnerable population of BZD misuse in Bangladesh. The aim of the s...
LIQUISOLID TECHNIQUE FOR DISSOLUTION AND BIOAVAILABILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS
Liquisolid formulations have attracted substantial interest as an efficient means of improving the dissolution and ultimately bioavailability. The technique is based upon the admixture of drug loaded solutions with appro...
IN -VIVO ANTI-DIARRHOEAL ACTIVITY OF METHANOL EXTRACT OF BOMBAX BUONOPOZENSE
Diarrhoeal disease is responsible for mortality and morbidity, especially among children in developing countries causing a major healthcare problem. The purpose of the present study was to evaluate anti-diarrhoeal effect...
WOUND DRESSINGS UPLOADED WITH MYRTLE BERRIES EXTRACT AND NIGELLA SATIVA HONEY
Wound dressings are frequently developed by introducing new products to target different aspects of the wound healing process. Many medicated dressings incorporated with natural extracts and chemicals have been developed...