EVALUATION OF METHANOLIC EXTRACT OF EUPHORBIA NERIIFOLIA STEM BARK ON BLOOD SUGAR LEVELS, SERUM AND TISSUE LIPIDS IN A PRECLINICAL MODEL
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 3
Abstract
The present study is undertaken to evaluate the effect of Euphorbia neriifolia stem bark on blood glucose and lipid levels in experimental diabetic rats. Methanolic extract of Euphorbia neriifolia stem bark (MEEN) was administered at different doses and its effect on blood glucose, haemoglobin, serum and tissue lipids, hexokinase and glucose-6-phosphatase in streptozotocin-induced diabetic rats were studied. Glibenclamide was used as standard reference drug. Euphorbia neriifolia methanolic extract (MEEN), at doses of 100,200 and 400mg/kg body weight for 30 days, suppressed the elevated blood glucose and lipid levels in diabetic rats. Euphorbia neriifolia at 400mg/kg was found to be comparable to glibenclamide. The study indicates that the Euphorbia neriifolia possess antihyperlipidaemic effect as well as antidiabetic activity.
Authors and Affiliations
M. Salim Mirza, Sayed Ayaz Ali, Indrajeet Sanghvi
Keywords
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- EP ID EP36389
- DOI https://doi.org/10.22270/ujpr.v2i3.R1
- Views 275
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