EFFECTS OF EMODIN ON BLOOD GLUCOSE AND BODY WEIGHT IN TYPE 1 DIABETIC RATS
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 4
Abstract
Objective of present study was to analyze the effect of emodin on blood glucose and body weight in rats with type 1 diabetes. A total of 45 healthy SD rats were selected followed by being adaptively fed for one week and then from them 15 rats were randomly selected out as the control group and the remaining 30 healthy SD rats were given intraperitoneal injection of streptozotocin to establish diabetic model with the control group receiving intraperitoneal injection of citrate buffer solution of same doses; At the fifth day, the rats were fasted for 6h and appropriately fed with water. Then the tail blood was collected to measure the fasting blood glucose of rats and this step was repeated 15 days after the injection of streptozotocin. The diabetic rat model was established successfully when the blood glucose was detected to be no less than 16.9mmol/L; thirty diabetic model rats were randomly divided into diabetes group and emodin group with 15 cases in each group (n = 15); 15 days later, the rats in diabetes group and control group were treated with intragastric administration of PBS, 5ml/kg, and the rats in emodin group were given intragastric administration of emodin suspension (8g/L), 5ml/kg. The changes of fasting blood glucose and body weight were observed and compared in three groups from the time point of before model establishment to fifth and fifteenth days after successful establishment of model. There was no significant difference among three groups in fasting blood glucose and body weight at the initial stage of establishing model; In diabetes group and emodin group, the rat’s body weight in T2 was significantly lower than that in T1 with the body weight decreasing more significantly in diabetes group (P<0.05), while the blood glucose in T2 was significantly higher than that in T1 with the blood glucose increasing more significantly in diabetes group (P<0.05). Emodin can relieve hyperglycemia in type I diabetic rats but has little influence on body weight.
Authors and Affiliations
Kaijian Hou, Chao Chen, Xuhuang Wang, Yuanyuan Guo
Keywords
Related Articles
- EP ID EP36399
- DOI https://doi.org/10.22270/ujpr.v2i4.R3
- Views 281
- Downloads 0
THE IMPACT OF HOSPITAL INFORMATION SYSTEM ON THE WORKING PROCESS OF IMAM JA’FAR SADIQ HOSPITAL, ALBORZ PROVINCE - 2016
This research has been done on the impact of the hospital information system on the staffing of Imam Ja’far Sadiq Hospital in Alborz in 2016. The research method is applied and in terms of data collection method, descri...
Editorial Message...
It is great honor and high pleasure to be appointed as member- Editorial Board, then as executive editor, Universal Journal of Pharmaceutical Research (UJPR). My heartiest salutations and warm congratulation to all edito...
THE EFFECT OF TRAFFIC FACTORS AND TECHNOLOGY FACTORS ON CHRONOLOGICAL DELAY OF EMERGENCY (115) ON THE BESIDES OF INJURED PEOPLE IN BOYER AHMAD CITY IN 2017
The aim of this study is to investigate traffic factors and technology factors on chronological delay of emergency (115) on the besides of injured people in Boyer Ahmad city in 2017. The research method of this investiga...
A CROSS-SECTIONAL STUDY ON BENZODIAZIPINE (BZD) ABUSERS OF DHAKA CITY: A SOCIO-PSYCHOLOGICAL CONDITION OF BANGLADESH
Benzodiazepines (BZD) are highly potential drug for abuse among the most frequently prescribed medicine. Different studies say that young-adults are the vulnerable population of BZD misuse in Bangladesh. The aim of the s...
SOLID DISPERSION TECHNOLOGY, A CONTEMPORARY OVERVIEW ON A WELL ESTABLISHED TECHNIQUE
Solubility is a significant physicochemical parameter that affects the absorption, bioavailability and therapeutic effectiveness of any drug. Formulation development would fail if drug has a poor aqueous solubility. The...