SERUM POSITIVITY OF ANA AND ASMA AMONG KHAT AND NONKHAT CHEWERS AS MARKERS FOR AUTOIMMUNE HEPATITIS TYPE 1
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 4
Abstract
Autoimmune hepatitis (AIH) is a necroinflammatory liver disease of unknown etiology. It has been proposed that certain herbs such as black cohosh and dai-saiko might trigger AIH. Khat is an ever green tree whose leaves have been chewed by people in Yemen where AIH is common. Aim of present study was to measure antinuclear antibodies (ANA) and anti-smooth muscle antibodies (ASMA) as serum markers for AIH type1 in healthy people who chew and do not chew khat. It also aimed to determine some other risk factors for ANA and ASMA positivity. A total of 100 healthy individuals were enrolled in this study. They were divided into: Daily khat chewers and non-khat chewers. Three ml peripheral blood was withdrawn from each participant. Blood samples were tested for ANA and ASMA using indirect immunofluorescence assay.The age of khat chewers ranged from 30-60 years with mean age 40.4±7.6 years. Non-khat chewers age ranged from 30-57 years with mean age 39.9±6.2 years. The majority of khat chewers and non-chewers were in age groups 30-39 and 40-49 years old. There is no association between khat chewing and ANA or ASMA serum positivity (χ2 = 0.33, P = 0.39 and χ2 = 1.5, P = 0.16; respectively). However, ANA and ASMA positivity were significantly increased with age of the participants (χ2 = 7.79, P = 0.044 and χ2 = 10.6, P = 0.011, respectively). khat chewing has no association with ANA and ASMA positivity. Nevertheless, ANA and ASMA positivity has an association with aging.
Authors and Affiliations
Arwa M Othman, Eman A Hamzah, Jamil A Almughales, Abdullah Al-Mikhlafy
Keywords
Related Articles
- EP ID EP36401
- DOI https://doi.org/10.22270/ujpr.v2i4.R5
- Views 296
- Downloads 0
INVESTIGATING THE OBSTACLES OF IMPLEMENTING HEALTH INFORMATION SYSTEMS FROM VIEWPOINT OF PERSONNEL OF MEHRIZ HEALTHCARE SYSTEM IN 2017
Health centers have a special significance as one of main organizations of providing services and first line of access to services for people. These centers severely require using various means of information systems due...
COMPARISON OF THE KNOWLEDGE, ATTITUDE AND PERFORMANCE OF HOSPITAL MANAGERS IN BUSHEHR PROVINCE ABOUT NOSOCOMIAL INFECTIONS
Nosocomial infections are one of the social and economic medical problems in developing countries, which contribute to the spread of infectious diseases and long hospitalization and mortality among patients. The aim of t...
DEVELOPMENT AND EVALUATION OF FAST DISSOLVING THIN FILMS OF ARIPIPRAZOLE
In the current pharmaceutical research fast dissolving films are playing an important role. In the present research, five different rapidly dissolving films of Aripiprazole were prepared successfully by using different p...
DEVELOPMENT AND CHARACTERIZATION OF MUCOADHESIVE PATCHES FOR BUCCAL DELIVERY OF PREGABALIN
Pregabalin is a structural analogue of the inhibitory neurotransmitter γ-amino butyric acid (GABA) having short half-life (5-6 hrs) and is used in the management of epilepsy. The aim of this study was to prepare a buccal...
ANTIMICROBIAL ACTIVITIES FOR HADHRAMI HONEY ON GROWTH OF SOME PATHOGENIC BACTERIA
The majority of the Yemeni honey varieties are characterized by low moisture content, in addition to the various flora of Yemeni plant, which may not be found in many countries, which makes them of high medicinal importa...