DESIGN AND EVALUATION OF CARBAMAZEPINE LOZENGES
Journal Title: Universal Journal of Pharmaceutical Research - Year 2017, Vol 2, Issue 5
Abstract
Lozenges are the flavoured solid, unit dosage medicated dosage forms usually in the sweetened base intended to be sucked and held in the mouth or pharynx containing one or more medicaments. Lozenges were developed in 20th century and is still under commercial production. These are medicated confections designed for local as well as systemic therapy. Carbamazepine (CBZ) is an anticonvulsant drug used in the treatment of epilepsy and neuropathic pain. It is used in schizophrenia along with other medications. In the present study an attempt has been made to prepare and evaluate the sugar based medicated Carbamazepine lozenzes to improve bioavailability and increase patient compliance specially for those patients who have difficulty in swallowing. The lozenges were prepared using sucrose as base; HPMC K4M, methyl cellulose were used as polymers. Eudragit was used as taste masking agent. Formulations were prepared by heating and congealing method on laboratory scale All the formulations prepared were subjected to various physicochemical parameters like hardness, friability, weight variation, drug content and in vitro dissolution studies. Stability studies of selected formulations of batch CL4 were also carried out at 40/75% relative humidity for 6 months for a period of six months. There wasn’t any substantial interaction between the drugs, flavor and color and other parameters and the prepared formulations were found to be stable.
Authors and Affiliations
Onyeka Ifeanyi Peter, Ukwe Chioma Ifeoma
Keywords
Related Articles
- EP ID EP36409
- DOI https://doi.org/10.22270/ujpr.v2i5.R1
- Views 305
- Downloads 0
ORAL C.ALBICANS COLONIZATION AND NON-CANDIDA ALBICANS CANDIDA COLONIZATION AMONG UNIVERSITY STUDENTS, YEMEN
Candida albicans is diploid yeast that in some circumstances may cause oral or oropharyngeal infections. This investigation aimed to study the oral C. albicans colonization (OCC) and Non-Candida albicans Candida coloniza...
THE EFFECT OF HOSPITAL MANAGERS' SUCCESSION PLANNING ON ORGANIZATIONAL PERFORMANCE: A CASE STUDY OF SHOUSHTARI MATERNITY HOSPITAL IN SHIRAZ IN 2017
Widespread and rapid changes that have been created in current organizations, have led to feel lack of managers with skill for key jobs of organization and hence about the importance of succession planning in organizatio...
DEVELOPMENT AND EVALUATION OF ALBENDAZOLE MICROCAPSULE FOR COLONIC DRUG DELIVERY SYSTEM
At present scenario colon specific drug delivery has gained increased importance. Colon drug delivery system not only used for the treatment of local diseases, associated with the colon but also it is a potential site f...
DEVELOPMENT AND EVALUATION OF NANOEMULSION FORMULATIONS FOR IMPROVED ORAL DELIVERY OF CARVEDILOL
The aim of the present investigation was to develop, optimize and evaluate nanoemulsion system of carvedilol to improve its solubility, and oral bioavailability. Carvedilol is a non-selective beta blocker used in the tr...
LEAD ACETATE: A DANGEROUS ENVIRONMENTAL TOXICANT THAT IS AMELIORATED BY THE AQUEOUS EXTRACT OF FICUS VOGELII (FV)
The aim of the present study was to investigate the effects of lead toxicity on the histoarchiteture of the vagina and cervix of adult female Wistar rats and the currative role of Ficus vogelii (Fv) in lead toxicity. The...