In the frame work of a general and wholly therapeutic program, that is necessary for treatment of mentally retarded children, the remedial therapy i. e. medical treatment has jet its important role, very often estimated according the possibilities in this field, but in the frame work of all the other therapeutic procedures will have its own place for a long time further on. The most used is psychopharmaco therapy, which is used as necessary, for symptomatic activities, very often in the sphere of behavior or different implanted psychopathological disorders of mentally retarded children. The priority is given to the non sedative high potential neuroleptocytes. The group of basic sedative low potential neuroleptocytes should be avoid, because of the shown sedation, which has an negative influence towards the cognition and learning, which are already damaged in mentally retarded children. We treat conditions of neurotic of these children with “anksiolitici” and “tranklizeri”. We should be very cautions using these drugs from the group of “benzodiazemini”, because of the possibility of development of tolerance and possible dependency.