Macedonian Journal of Medical Sciences (MJMS)

Macedonian Journal of Medical Sciences (MJMS)

Basic info

  • Publisher: Institute of Immunobiology and Human Genetics, Faculty of Medicine, Ss Cyril and Methodius University – Skopje
  • Country of publisher: macedonia, the former yugoslav republic of
  • Date added to EuroPub: 2017/May/14

Subject and more

  • LCC Subject Category: Epidemiology, Physiology
  • Publisher's keywords: medical sciences, Physiology
  • Language of fulltext: english
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): Yes 200 EUR
  • Submission charges: No
  • Waiver policy for charges? No

Editorial information

Open access & licensing

  • Type of License: Other
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2008
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: None
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: None

This journal has '294' articles

Sixty Years Faculty of Medicine in the Republic of Macedonia (1947–2007)

Sixty Years Faculty of Medicine in the Republic of Macedonia (1947–2007)

Authors: Dejan Trajkov| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “St. Kiril and Metodij”, Skopje, Republic of Macedonia,...
( 22 downloads)
Abstract

Faculty of Medicine in Skopje, Republic of Macedonia was founded in 1947 year with its educational and health activities which should lead to improvement of the health care in the country. In the past sixty years Faculty of Medicine changed its structure, position, and the role several times in order to fulfill the needs of the society for continous increase of quantity and quality of tertiary health care, education of medical students, as well as research in the biomedical fields. Today, the organizational structure of the Medical Faculty consists of 12 institutes and 3 teaching bases in the pre-clinical department and 25 clinics, 3 institutes and 7 teaching bases which take active part in both, education and scientific activities. Altogether there are 33 departments which perform the entire educational (undergraduate, postgraduate, specialization and sub-specialization), scientific and providing health activities. These 33 departments are actively involved in the realization of the study programmes, not only at the Medical Faculty, but the Faculty of Stomatology, Pharmaceutical Faculty, the Faculty of Natural Sciences, and the Faculty of Physical Culture as well. Medical Faculty is a member of the European and the global family of institutions of this kind.

Keywords: Faculty of Medicine, Education, Health protection, Science, Republic of Macedonia
Macedonian Biomedical Scientists Are Not Adequately Represented in BiomedExperts Database

Macedonian Biomedical Scientists Are Not Adequately Represented in BiomedExperts Database

Authors: Mirko Spiroski| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia
( 22 downloads)
Abstract

Aim. The aim of this study was to analyze publication activity of Macedonian biomedical scientists reported in BioMedExperts and to propose improvements and corrections in order to present Macedonian science more objectively. Material and methods. For this investigation BiomedExperts database was searched for scientific experts in a total of 145 countries, as well as scientific profiles originating from Republic of Macedonia (June 17, 2008). Affiliation in Macedonia concerned number and %, first authors, middle authors, last authors and coauthors were analyzed. Results. Macedonian authors with 410 papers contribute with 0.006% in the BiomedExperts. All neighboring countries, except Albania (0.001%), have higher percentage of scientific papers in BiomedExperts: Greece (0.468%), Serbia (0.111%), and Bulgaria (0.092%). We can see that only 54 scientists are presented under the name of Republic of Macedonia. They published 825 scientific papers, from which 580 are affiliated with the Republic of Macedonia (70.3%). Most of the Macedonian biomedical scientific authors (7.50) are middle authors, much less are first authors (4.06) and the rest of the authors are last authors (3.72). Macedonian biomedical scientists in average have 14.69 co-authors in their scientific papers. Conclusion. Macedonian biomedical scientists are not adequately represented in BiomedExperts database and scientists are encouraged to register, log in, and correct personal profiles.

Keywords: Macedonian biomedical scientists, scientific social network, scientific database, bibliometrics, Republic of Macedonia
Aberrant Expression of Polycystin-1 in Renal Cell Tumors

Aberrant Expression of Polycystin-1 in Renal Cell Tumors

Authors: Jean Gogusev| INSERM U507, Hôpital Necker France, Yves Chretien| Service d’Urologie, Hôpital Necker France, Dominique Droz| INSERM U507, Hôpital Neck...
( 22 downloads)
Abstract

Polycystin-1 (PC1) is a cellular transmembrane protein coded by the polycystic kidney disease (PKD1) gene, prevalently expressed in developing/mature kidney and in autosomal polycystic kidney disease (ADPKD). Limited data are available concerning the PC1 involvement in renal tumorigenenesis. Polycystin-1 expression was evaluated in 8 clear cell renal cell carcinomas (RCCs), 7 tubulopapillary cell type tumors, 3 solid RCCs developed in patients with von Hippel-Lindau disease (VHLD), one RCC developed in a patient on chronic haemodialysis and one angiomyolipoma in a patient with Tuberous sclerosis (TS). In the normal kidney, consistent level of polycystin-1 was detected in distal tubules, collecting duct, glomerular podocytes and vascular smooth muscle cells. The strongest immunoreactivity against polycystin-1 was observed in epithelial cells lining the cystic components in all ADPKD tissues. Five cases of clear cell type RCCs and two-tubulopapillary cell type RCCs consistently expressed PC1. In the VHL disease associated renal carcinomas, both the neoplastic cells and cystic tissue areas weakly expressed PC1. In TS-associated angiomyolipoma, the vascular component was PC1 positive, while the tumoral cells were scarcely stained. The present report indicates consistent expression of the PKD1 gene product polycystin-1, in normal kidney, ADPKD tissues, and renal cell carcinomas. The findings suggest that the level of PC1 expression is linked to tumor cell type, being a more frequent event in clear cell RCC.

Keywords: Polycystin-1 (PC1), Autosomal plycystic kidney disease (ADPKD), Renal Cell Carcinoma (RCC), von Hippel-Lindau disease, Immunohistochemistry
IL-1 Gene Cluster Polymorphisms in the Macedonian Population

IL-1 Gene Cluster Polymorphisms in the Macedonian Population

Authors: Dejan Trajkov| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “St. Kiril and Metodij”, Skopje, Republic of MacedoniaFr...
( 22 downloads)
Abstract

The aim of this study was to genotype IL-1 gene cluster polymorphisms in the Macedonian population. A group composed of 301 healthy unrelated individuals was selected. IL-1 genotyping of the samples was performed by the PCR-SSP procedure followed by analysis of the IL-1 data with the PyPop population genetic analysis software package. The frequency of IL-1 alleles varies from 0.814 for IL1A -889/C, 0.729 for IL-1B +3962/C, 0.698 for IL-1RN mspa 11100/T, 0.671 for IL-1B -511/C, followed by 0.663 for IL-1R psti 1970/C indicating common “wild type” allele. We determined 27 different haplotypes from the total number of 32. The most frequent haplotypes for IL-1 are CCCCT (0.191), CTCCT (0.127), CCCTT (0.098), CCCCC (0.085), CTCTT (0.082). All pairs of loci for IL-1, except for IL-1R psti 1970, are in linkage disequilibrium, with p<0.05. The closest genetic distance is observed between the studied Macedonian population and the population from ItalyTorino, while the most genetically distant populations were TaiwanTsou, and TaiwanYami. It is concluded that IL-1 cluster alleles, genotypes, and haplotypes in Macedonian population show a good concordance with Hardy Weinberg equilibrium and can be used for anthropological comparisons, as well as for association studies with different diseases.

Keywords: IL-1 gene polymorphisms, SSP genotyping, Macedonian population, Molecular anthropology, Human genetics
Chronic Graft-Versus Host Disease - Single Center Experience

Chronic Graft-Versus Host Disease - Single Center Experience

Authors: Zlate Stojanoski| Hematology Clinic, Medical Faculty, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Svetlana Krstevska-Balkanov| I...
( 22 downloads)
Abstract

Background. With the increasing number of patients surviving peritransplant complications of stem-cell transplantation (SCT), the incidence of chronic Graft Versus Host Disease (cGVHD) has increased too. cGVHD now develops in approximately 30-50% of patients undergoing SCT. Risk factors associated with the development of cGVHD are: previous acuteGVHD (aGVHD), prior cytomegalovirus infection, use of a matched unrelated donor and combination of a male recipient with a female donor. Not all patients who develop aGVHD progress to cGVHD. The latter may occur de novo. Aim. To describe clinical and patohistological findings and influence of cGVHD on survival in allogeneic stem cell recipients. Material and methods. During 7 years period we have treated 40 patients with allogeneic SCT from HLA identical sibling. aGVHD prophylaxis comprised Seattle protocol. Results. 12 patients (6 males, 6 females; mean age: 34,5) developed cGVHD (7 de novo). Distribution according to diagnosis: Acute Myeloid Leukemia (n=8), Chronic Myeloid Leukemia (n=3), Primary myelofibrosis (n=1). Six of them had limited disease, and 6 had extensive. Treatment comprised: corticosteroids + CsA (6), Mophetyl mycophenolate (4), Tacrolimus (2), Photochemiotherapy (3). 10 (83%) patients are alive; 2 (17%) died. Conclusion. Despite advances in histocompatibility matching and immunosuppressive drugs, GVHD has continued to be a common and often lethal complication of SCT.

Keywords: allogeneic stem cell transplantation, graft versus host disease
Presence of Chlamydia Trachomatis in the Women’s Urethra During a Concomitant Generic Infection of Cervix Uteri

Presence of Chlamydia Trachomatis in the Women’s Urethra During a Concomitant Generic Infection of Cervix Uteri

Authors: Dragan Tanturovski| Clinic of Gynecology and Obstetrics, Medical Faculty - Skopje, Republic of Macedonia, Tatjana Grdanoska| Institute of Microbiolog...
( 24 downloads)
Abstract

The objective of our research was to determine the presence of Chlamydia trachomatis in the women’s urethra in patients with an infection of cervix but without symptoms for a urinary infection. The study included 74 patients, 46 (62%) of which had subjective symptoms and 28 patients (38%) that didn’t have subjective symptoms for a genital infection. Urethral and cervical swabs were taken from all the patients included in the study. Chlamydia trachomatis was isolated from 18 patients (24.3%). Of these 18 patients, 10 patients had symptoms for a genital infection and 8 patients didn’t have symptoms for a genital infection. Chlamydia trachomatis was detected both in cervix uteri and the urethra in 16 patients, only in cervix uteri in one patient and only in the urethra in one patient. The obtained data shows that there is no significant difference in the presence of Chlamydia trachomatis in the groups of patients with and without symptoms for a genital infection, as well as a high degree of correlation between the presence of Chlamydia trachomatis in the urethra and cervix uteri, which in turn allows the introduction of the method of taking a urethral swab to detect Chlamydia trachomatis as a screening method.

Keywords: Genital infection, Chlamydia trachomatis, urethra, screening method
Different Ankle Brachial Index Levels in Asymptomatic Hemodialysis Patients

Different Ankle Brachial Index Levels in Asymptomatic Hemodialysis Patients

Authors: Saso Gelev| Department of Nephrology, Clinical Center, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Goce Spa...
( 22 downloads)
Abstract

Resting ankle brachial systolic pressure index (ABI) level of 0.90 is 95% sensitive in detecting angiogram-positive peripheral arterial disease (PAD) and that falsely elevated pressures or incompressible arteries at the ankle level and ABI > 1.30 is caused by mediosclerosis. We evaluated 94 hemodialysis (HD) patients for the presence of PAD and mediosclerosis using ABI measurement, and the presence of atherosclerotic lesions using high resolution B-mode ultrasonography of the common carotid (CCA) and femoral arteries (FA). Asymptomatic HD patients with high ABI (mediosclerosis) and low ABI (PAD) levels were common. Patients with normal and high ABI levels had high percentage of atherosclerotic lesions. Older age, diabetes and low serum albumin, and higher doses of prescribed calcium carbonate were associated (p<0.05) with low levels of ABI in our HD patients. Male gender, higher blood pressure and presence of diabetes were associated (p<0.05) with high ABI levels. Low and high ABI levels were not associated with the specific risks such as elevated serum phosphate , calcium phosphate product and intact parathyroid hormone levels. Arterial disease in asymptomatic HD patients is frequent. Screening for atherosclerotic lesions in HD patients should be recommended even if they had no symptoms.

Keywords: Hemodialysis, arterial disease, ankle brachial index
Antifungal Prophylaxis In Hematopoietic Stem Cell Transplant Recipients

Antifungal Prophylaxis In Hematopoietic Stem Cell Transplant Recipients

Authors: Zlate Stojanoski| Hematology Clinic, Medical Faculty, University St’s Cyril and Methodius, Skopje, Aleksandra Pivkova| Hematology Clinic, Medical Facu...
( 21 downloads)
Abstract

Background. According to immunological deficit the period after hematopoietic stem cell transplantation (HSCT) can be divided in three phases: aplastic phase, phase of acute GVHD, and phase of chronic GVHD. Fungal infections are predominant in first, aplastic phase. Deep neutropenia and implantation of central venous catheter are two major risk factors contributing to infection. Aim. To retrospectively analyze fungal infections, fungal isolates and to compare success of different antifungal strategies during the first 30 days after HSCT. Material and methods. During a 7 year period (2000-2007), we have performed 128 HSCT in 120 patients with different hematological diseases. Male: 62 Female: 58. Median age: 34 years. Patients were treated in sterile room, conditioned with HEPA filters, and low microbes diet. Antifungal prophylaxis with Fluconazole 200mg, Itraconazole 200mg, or combination Fluconazole200/Itraconazole 200 (in high-risk patients) was administered from day 0 until day +100. Results. Patients treated with combination of Fluconazole200/Itraconazol200 have had only few oropharyngeal candidiasis, without signs of invasive fungal infection. There is no statistically significant difference between the prophylaxis with Fluconazole and Itraconazole, (p=0,302). Non-Albicans Candida is predominantly isolated funga (Non-Albicans Candida vs. Candida Albicans: 54% vs. 46%). There is no isolation of Aspergillus during the first phase after HSCT in our group of patients. Concluson. The rising incidence of invasive fungal infections and the currently problematic early diagnosis call for an intensive exploration of new drugs and further developments in diagnosis and treatment of invasive fungal infection.

Keywords: fungal infections, stem-cell transplantation
Alpha-1-Antitrypsin Deficiency: A Case of a Two-year Old Boy with Inherited Disease

Alpha-1-Antitrypsin Deficiency: A Case of a Two-year Old Boy with Inherited Disease

Authors: Aleksandar Petlichkovski| nstitute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Ma...
( 18 downloads)
Abstract

Alpha-1-antitrypsin (AAT) is a protease inhibitor which plays an important role of protector of the lung tissues against the proteolytic effect of elastase secreted from neutrophils. Its deficiency is associated with liver disease in children and emphysema in adults. So far, more than 75 variants of this protein are defined, but most of the cases of AAT deficiency are caused by homozygosis for the deficient allele PIZ or by heterozygous combination of the 2 most common deficient alleles, PIS and PIZ. A diagnosis in the case of a suspicion of AAT deficiency is carried out by measuring the alpha-1 antitrypsin level in blood and by genotyping the alpha-1 antitrypsin alleles. The importance of early diagnosis resides in the possibility of undergoing a lifestyle modification (such as vigorous smoking cessation, for example) and treatment of pulmonary disease thus significantly decreasing the morbidity. The family studying is important to identify individuals at high risk, and initiation of AAT replacement therapy in individuals. Having in mind the underdiagnosis of this disease, we hope to contribute with this case report to the medical community in Republic of Macedonia to raise the awareness of this disease, and also of the possibilities of exact diagnosis.

Keywords: AAT deficiency, PIZ, PIM, PIS, hybridization assay, AAT genotyping
Osteoskeletal Manifestation of Scurvy in a Male Infant (Case Report)

Osteoskeletal Manifestation of Scurvy in a Male Infant (Case Report)

Authors: Nada Pop-Jordanova| Pediatric Clinic, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Nevenka Slavevska| Pediat...
( 19 downloads)
Abstract

Scurvy, a disease of dietary deficiency of vitamin C, was uncommon in the last century due to improved nutrition and health care. However, in the last decade it was increasingly reported in adult population. In a period of infancy, scurvy appears after the age of five months and is related mainly to malnutrition. The main symptoms are vascular purpura, bleeding and gum abnormalities, but musculoskeletal manifestations could also be prominent. Children experience severe lower limb pain related to subperiosteal bleeding. The misdiagnosis with rickets and arthritis is common. We present a case of scurvy in 8 month boy with osteoskeletal manifestation, very rare seen in contemporary European pediatrics. The diagnosis of our patient is made by clinical presentation (such as haematuria, edema of lower extremities as well as swollen right leg), some biochemical parameters and radiological finding. The therapeutically outcome and follow-up of the boy confirmed the diagnosis and etiology.

Keywords: Scurvy, osteoskeletal problems, infant
Homocysteinemia and Methylentetrahydrofolate Reductase Gene Mutation as a Risk Factor for Blood Vessel Disease

Homocysteinemia and Methylentetrahydrofolate Reductase Gene Mutation as a Risk Factor for Blood Vessel Disease

Authors: Sloboda Dzhekova-Stojkova| 1Institute of Medical and Experimental Biochemistry, Faculty of Medicine, University “Ss Kiril and Methodij”, Skopje, Repub...
( 22 downloads)
Abstract

The aim of the project was to investigate homocysteinemia and Methylentetrahydrofolate reductase (MTHFR) gene (C677T) mutation with vascular diseases. The investigation comprised a total number of 378 subjects divided into two main groups: 194 healthy individuals and 184 patients: 91 with arterial occlusive disease (AOD) and 93 with thrombosis of deep vein (TDV). Concentration of total homocysteine (tHcy) in plasma was determined using the modified immunoenzyme method. Mutation of MTHFR C677T was examined with polymerase chain reaction with CVD StripAssay (ViennaLab Labordiagnostika GmbH) as a segment of 12 mutations of the cardiovascular system. Concentration of tHcy in patients with AOD was 16.3 ± 8.4 μmol/L in men, 14.1 ± 3.3 μmol/L in women and it was statistically significantly increased as compared to healthy subjects from the same gender (p<0.001). Concentration of tHcy in men with TDV was 14.0 ± 3.5 μmol/L, 13.4 ± 3.0 μmol/L in women and it was significantly increased in comparison to healthy subjects (p<0.001). Concentration of homocysteine in plasma of healthy subjects with different genotype of MTHFR C677T showed significantly higher values for TT when compared to CC genotype as well as to CT genotype. Comparison between healthy and sick individuals both separately, AOD and TDV, or as one entity, showed significantly higher values for the genotypes CC and CT, but not for the TT genotype. There was no correlation of MTHFR C677T gene mutations with AOD and TDV.

Keywords: Total homocysteine, immuno-enzyme method, reference values, arterial occlusive disease, thrombosis of deep veins, mutation
60. Years (1945-2005) Macedonian Medical Association

60. Years (1945-2005) Macedonian Medical Association

Authors: Aleksandar Petlichkovski| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of M...
( 21 downloads)
Abstract

This year the monographic book “60 Years Macedonian Medical Association 1945- 2005” was published, denoting more then six decades successful existence of Macedonian Medical Association (MMA). In the period behind us, the MMA has been bearer of the continuous development and growth of the health provision system. Starting its activities back in 1945, with only 123 doctors and dentists working in Republic of Macedonia, the MMA today represents more then 5000 doctors, of whom 3025 are specialists in various fields. The doctors in the MMA are organized into 22 regional or local associations and 70 specialist and sub-specialist associations. The MMA was the predecessor of the Faculty of Medicine in Macedonia, with the vast majority of the staff being recruited from MMA. A major contribution to the professional and scientific development of the medical profession in Macedonia was achieved through the introduction of the scientific journal and organization of scientific congresses under auspice of MMA. Today MMA is an active participant, initiator and consultant in the creation and improvement of the laws regulating the health service provision in the country. The highest state honour, the 11th October Award was awarded to MMA, as recognition for its continuous commitment to progress of Macedonian medicine.

Keywords: Medical Association, 60. Years Macedonian Medical Association, Republic of Macedonia
Macedonian Medical Journals Have Very Limited Scientific Influence

Macedonian Medical Journals Have Very Limited Scientific Influence

Authors: Mirko Spiroski| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia,...
( 22 downloads)
Abstract

Aim. The aim of this report was to evaluate the Macedonian medical journals for their scientific influence according to the internationally recognized citation metrics indexes. Material and methods. Macedonian medical journals were analyzed, and eight of them fulfilled criteria for more detailed study of their scientific influence. Citation metrics indexes h-index, g-index, hc-index, hl-index, and hl, norm were performed using Publish or Perish, a software that retrieves and analyses academic citations. Macedonian medical journals were then compared to the Croat Med J. Results. Only three Macedonian medical journals were indexed in Medline/PubMed (Maked Med Pregl, God zb Med fak Skopje, and Prilozi) and only one is indexed in Index Copernicus (Maced J Med Sci). Most of Macedonian medical journals are not members of the international organizations and do not follow international standards for scientific publications. All Macedonian medical journals have 5 to 10 times smaller citation metrics indexes (h-index, g-index, hc-index, hI-index, and hI, norm) if compared with Croat Med J. There are not big differences in citation metrics indexes between Macedonian medical journals. Conclusion. Macedonian medical journals have very limited scientific influence and their Editorial Boards are obliged to improve quality of their published manuscripts, and to adhere to international standards for scientific journals, which will result in their greater visibility and scientific influence

Keywords: Macedonian medical journals, Scientific papers, Citation metrics, Croatian Medical Journal, Republic of Macedonia
Telomerase Activity and MDS/EVI Gene Fusion in Myelodysplastic Syndrome. Correlation to the Immunohistochemical Expression of Ki-67, Bcl-2 and p53 in Bone Marrow Biopsy Samples

Telomerase Activity and MDS/EVI Gene Fusion in Myelodysplastic Syndrome. Correlation to the Immunohistochemical Expression of Ki-67, Bcl-2 and p53 in Bone Marrow Biopsy Samples

Authors: Rubens Jovanovik| Institute for Pathology, Faculty of Medicine, University “Ss Kiril and Metodij”, Skopje, Republic of Macedonia, Vesna Jane...
( 22 downloads)
Abstract

Background. Myelodysplastic syndrome (MDS) as a complex disorder comprised of 7 entities may arise as a primary disorder, or in a setting of an underlying disease, or as therapy related (secondary MDS). Some cases show MDS/EVI1 gene fusion, and some studies have pinpointed the association between the high-risk MDS and increased telomerase activity. Aim. To determine the frequency of MDS/EVI1 gene fusion in cases of primary MDS, and to evaluate the possibility for detection of increased telomerase activity in peripheral blood samples from patients with MDS. Material and methods. We isolated DNA from 35 bone marrow biopsies, and measured the blood telomerase activity (RTA) in 21 of the patients. We performed immunostainigs for Ki-67, Bcl-2 and p53 on the biopsy samples in order to test the correlations to the RTA and MDS/EVI1 presence. MDS/EVI1 fusion was detected with touch-down-direct PCR, and RTA was measured using the “TeloTAGGG-PCRELISA-plus kit”. Results. We found MDS/EVI1 fusion in 17.39% of high-risk MDS cases (overall 11.43%). RTA was highly variable in the analyzed group, with 1,8 fold increase of the mean RTA compared to the controls. It was due to the significant RTA increase in high-risk MDS cases, compared to the low-risk cases (p<0.01). Conclusion. RTA showed correlation to the immunohistochemical expression of Ki-67, and MDS/EVI1 fusion was correlated to the Bcl-2 expression.

Keywords: MDS/EVI1, gene fusion, telomerase, immunostaining, Ki-67; Bcl-2, p53
Comparison of Biofeedback Modalities for Better Achievement in High School Students

Comparison of Biofeedback Modalities for Better Achievement in High School Students

Authors: Nada Pop-Jordanova and Irena Chakalaroska| Department of Psychophysiology, Paediatric Clinic, Faculty of Medicine, University “Ss Kiril and Metodij”,...
( 19 downloads)
Abstract

The aim of this pilot study was to compare three biofeedback methods for enhancement of cognitive abilities (concentration and attention) in high school students. The sample comprises 50 students in high school for nurses, aged 16- 18 years, devised in three groups: I - 30 students trained with EEG-Peak Achievement Trainer (EEG-PAT); II - 10 students trained with Electrodermal Response Biofeedback (EDR); and III - 10 students trained with Heart Rate Variability (HRV). The EEG-PAT is supposed to activate the Executive Attention Network, while HRV and EDR were supposed to influence indirectly, through the stabilization of autonomous nervous system. As psychometric tests we used: Trail Making Test (form A and form B) and numbering forward and backward, each one applied prior and after the experiment. The obtained results suggested that EEG-PAT can be successfully used for improving the concentration and attention and to a less extend the Short Term Memory Span. The HRV showed modest improvement (only for numbers), and EDR group did not show significant improvement in the concentration, attention and the Short Term Memory Span. However, all the three methods are highly cost-benefit and very comfortable for application and can be used for stabilization of the homeostasis.

Keywords: Peak performance, EEG biofeedback, electrodermal resistance, heart rate variability

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