Indian Journal of Research in Pharmacy and Biotechnology

Indian Journal of Research in Pharmacy and Biotechnology

Basic info

  • Publisher: Indian Journal of Research in Pharmacy and Biotechnology
  • Country of publisher: india
  • Date added to EuroPub: 2017/May/21

Subject and more

  • LCC Subject Category: Biotechnology, Pharmacy
  • Publisher's keywords: Biotechnology, Pharmacy
  • Language of fulltext: english
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): Yes 50USD
  • Submission charges: No
  • Waiver policy for charges? No

Editorial information

Open access & licensing

  • Type of License: Other
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2013
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: None
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: Sherpa/Romeo

This journal has '510' articles

RECENT TRENDS OF POLYMER USAGE IN THE FORMULATION OF ORODISPERSIBLE TABLETS

RECENT TRENDS OF POLYMER USAGE IN THE FORMULATION OF ORODISPERSIBLE TABLETS

Authors: J.Preethi, MD Farhana, B.Chelli Babu, MD.Faizulla, Debjit Bhowmik, S.Duraivel
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Abstract

Disintegrants are an essential component to tablet formulations. While rapidly disintegrating tablets do not necessarily ensure fast bioavailability, slowly disintegrating tablets almost always assure slow bioavailability. The ability to interact strongly with water is essential to disintegrant function. Combinations of swelling and/or wicking and/or deformation are the mechanisms of disintegrant action. Super disintegrants offer significant improvements over starch. But hygroscopicity may be a problem in some formulations. Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. Disintegration remains a powerful influence and precursor for drug absorption. Disintegration of tablet or capsule is depending upon the type and quantity of disintegrants. The development of Orodispersible tablets provides an opportunity to take an account of tablet disintegrants. Therefore, there is a huge potential for the evaluation of new disintegrants or modification of an existing disintegrants into superdisintegrants, so as to formulate Orodispersible tablets. The present study comprises the various kinds of disintegrants and superdisintegrants, which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance.

Keywords: Super disintegrants, Polysorbate, Modified starches, Modified cellulose, Crospovidone
RECENT TRENDS IN USAGE OF POLYMERS IN THE FORMULATION OF DERMATOLOGICAL GELS

RECENT TRENDS IN USAGE OF POLYMERS IN THE FORMULATION OF DERMATOLOGICAL GELS

Authors: Shaik Arif Bhasha, Syed Abdul Khalid, S.Duraivel, Debjit Bhowmik, K.P.Samapth
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Abstract

Topical preparations can be applied directly to an external body surface by spreading, rubbing, and spraying. The topical route of administration has been utilized either to produce local effect for treating skin disorder or to produce systemic drug effects. Within the major group of semisolid preparations, the use of transparent gels has expanded both in cosmetics and in pharmaceutical preparations. Gels often provide a faster release of drug substance, independent of the water solubility of the drug, as compared to creams and ointments. They are highly biocompatible with a lower risk of inflammation or adverse reactions, easily applied and do not need to be removed. Gels for dermatological use have several favorable properties such as being thixotropic, greaseless, easily spreadable, easily removed, emollient, non-staining, and compatible with several excipients and water soluble or miscile. Dosage form selection should include those delivery systems that are noncomedogenic. Gels tend to be most effective as they have faster absorption than creams. Gels containing only water tend to be slow to dry; so the addition of ethyl or isopropyl alcohol to the gel hastens their drying to a film. But some patients may need the less drying lotions or creams for dry or sensitive skin or for use during dry winter weather.

Keywords: RECENT TRENDS, USAGE, POLYMERS, FORMULATION
ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITY OF TECOMA STANS LEAF EXTRACTS

ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITY OF TECOMA STANS LEAF EXTRACTS

Authors: V Lakshmi Prasanna1, K Lakshman, Medha M Hegde and Vinutha Bhat
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Abstract

Tecoma stans (Bignoniaceae) is used in the treatment of diabetes, stomach pains, rheumatism, diuretic, vermifuge and tonic in traditional medicine. The present study has been design to evaluate antinociceptive and anti-inflammatory activities of alcohol and aqueous extracts of Tecoma stans leaves and to determine total phenolic and flavonoid contents. Both extracts shows dose dependent activity. The antinociceptive activity was investigated using hot plate, acetic acid induced writhing and formalin induced paw licking methods. Anti-inflammatory activity was evaluated using carrageenan induced paw oedema method. Total phenolic and flavonoid content determined using standard chemical methods. Alcohol extract (500 mg/kg) showed highest 76.92% inhibition of inflammation after 24 hrs. Both the extracts produced increased in latency time compared to vehicle but alcohol extract showed highest activity after 150 min in hot plate method (4.63 ± 0.08 sec) and inhibit nocipeptive response in both phase. Extracts also produced significant inhibition of writhing. Content of total phenolic and flavonoid also found more in alcoholic extract. These findings demonstrate that the alcohol leaf extract of Tecoma stans have excellent antinociceptive and anti-inflammatory activity, which may due to presence of higher phenolic and flavonoid content.

Keywords: Tecoma stans leaves; antinociceptive; anti-inflammatory; phenolic content; flavonoid content
ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF PLANT KALANCHOE PINNATA (LAM) PERS IN MICE

ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF PLANT KALANCHOE PINNATA (LAM) PERS IN MICE

Authors: Shashank Matthew, Ajay Kumar Jain, Cathrin Matthew, M.Kumar, Debjit Bhowmik
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Abstract

The main objective of present work is to find out good pharmacological activities in herbal source with their preliminary phytochemical study, and also it is aimed to investigate anti-diabetic activity of ethenolic and aqueous extracts of dried stem of plant Kalanchoe pinnata (LAM)PERS against CNSDepressant activity in rats. Normally herbal products are free from side effects/adverse effects and they are low cost medicines, which will be beneficial for human being. The main objective of this work is to develop potent CNS-Depressant agent having no or minimum side effects from indigenous plants for the therapeutic management.

Keywords: Phytochemical study, Kalanchoe pinnata
A REVIEW ON COLLAGEN BASED DRUG DELIVERY SYSTEMS

A REVIEW ON COLLAGEN BASED DRUG DELIVERY SYSTEMS

Authors: Sahithi B, Ansari Sk, Hameeda Sk, Sahithya G, Durga Prasad M, Yogitha Lakshmi
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Abstract

Due to its biodegradability, biocompatibility, weak antigenicity and well-known safety profile, collagen becomes a very useful carrier for the delivery of various kinds of drugs and agents like growth factors, collagen possess some very unique properties as compare to other drug carriers that’s why a numerous number of researches are in pipeline on this biomaterial. The main application of collagen is collagen shields which are used in ophthalmology. However, fundamental awareness regarding collagen biochemistry and the manufacturing knowledge in combination with understanding of the physicochemical properties is essential for fruitful application of collagen for drug delivery systems. The purpose of this review article is to summarize information available on collagen dosage forms for drug delivery as well as to communicate an outline regarding current preparation of collagen available in market includes - collagen sponges for burns/wounds, mini-pellets and tablets, gel preparations in combination with liposomes for sustained delivery of drug, formulations for transdermal drug delivery, and Nano spheres for gene delivery, collagen matrices for cell culture

Keywords: Collagen, Drug delivery system, Biomaterial, Ophthalmology
RECENT TRENDS IN POSITIVE AND NEGATIVE ASPECTS OF FOOD ON BIOAVALABILTY OF DRUGS

RECENT TRENDS IN POSITIVE AND NEGATIVE ASPECTS OF FOOD ON BIOAVALABILTY OF DRUGS

Authors: Gowthami B Sk Nahida Fazilath Sanaulla Md K Prudhvi Raj Dastagiriah G Tabassum Sk
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Abstract

The therapeutic effectiveness of a drug depends upon the ability of the dosage form to deliver the medicament to its site of action at a rate & amount sufficient to produce the desired pharmacologic response. This attribute of the dosage form is referred to as Physiologic availability or Biologic availability or simply availability. For most of the drugs, the pharmacologic response is directly related to the plasma levels. Thus, the term, Bioavailability is defined as the rate & extent (amount) of absorption of unchanged drug from its dosage form. Bioavailability refers to the difference between the amounts of a substance, such as a drug, herb, or chemical, to which a person is exposed and the actual dose of the substance the body receives. Bioavailability accounts for the difference between exposure and dose. A drug's therapeutic action or a chemical's toxicity is determined by the dose received at the target site in the body. The dose at the target site is determined by the amount of the substance absorbed by the body, which depends on its bioavailability. If a substance is ingested, for example, its bioavailability is determined by the amount that is absorbed by the intestinal tract. If a substance is inhaled, its bioavailability is determined by the amount that is absorbed by the lungs. Understanding bioavailability is critical to determining the amount of a drug to administer or the level of chemical exposure that is likely to produce toxicity.

Keywords: Bioavailability, Bioavailability studies, Absolute and Relative bioavailability
A STUDY ON MEDICATION NON-ADHERENCE IN AMBULATORY DIABETIC PATIENTS AND NEED FOR PHARMACIST INTERVENTION FOR IMPROVING PATIENT ADHERENCE

A STUDY ON MEDICATION NON-ADHERENCE IN AMBULATORY DIABETIC PATIENTS AND NEED FOR PHARMACIST INTERVENTION FOR IMPROVING PATIENT ADHERENCE

Authors: Dr. Praveen Kumar G
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Abstract

Diabetes mellitus is a chronic disease and the prevalence for all age-groups worldwide was estimated to be 2.8% in 2000 and 4.4% in 2030. Medication non adherence is a pervasive medical problem that is common among patients with chronic disease. This study was conducted for a period of 1 month. It includes 154 randomly selected patients who were interviewed by using a questionnaire regarding socio-economic characteristics, adherence rates, barriers that affect adherence to medication use (using Morisky self report scale) and counseled by pharmacist for 20-30 minutes. Of the total, 97(62.9%) were adherent and 57(37.01%) were non adherent to medications. In our study the commonly cited intentional non-adherence was found to be self-decision(35.08%) and ommision of drugs because of experiencing Side effects (22.8%). Confusion in dosage frequency (17.5%), forgetfulness (10.5%) and financial difficulty (8.7%) were the other contributing factors for non-adherence. Efforts were taken to increase the medication adherence and self care through patient education by pharmacists. Patient’s medication compliance is a multifactor behavior in which the role of patient’s attitude is very important. Interventions are needed to increase medication adherence so that patients can realize the full benefit of prescribed therapies.

Keywords: Diabetes mellitus, non adherent, pharmacist
EVALUATION OF ANTI-ULCER EFFECTS OF ETHANOLIC EXTRACT OF DELONIX REGIA FLOWER

EVALUATION OF ANTI-ULCER EFFECTS OF ETHANOLIC EXTRACT OF DELONIX REGIA FLOWER

Authors: Samaresh Pal Roy Kamlesh Prajapati Ramji Gupta Dipanwita Bhadra, Nikunj Patel Archana Batiwala Gautam Sonara, Neerav Gheewala T. Kannadasan
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Abstract

Ulcer is one of the most common disorder in the world. The available antiulcer drug in the market have different side effect. So the people move to herbal drug for a better result and lesser side effect. Delonix regia is a plant from the family leguminosae is extensively available in the word. The earlier researcher found that the plant contain the chemical constitutent like tannin, saponin, flavonoid, so it have a good antioxident property. So, this study is planned recurred the antiulcer activity by ethanolic extract of the different doses (100mg/kg, 200mg,kg & 400mg/kg) of the flower of Delonix regia (EEDRF) on ethanol induced ulcer model in experimental rat whereas lansoprazole (8mg/kg) was taken as an standard drug. It has been found that the extract shows significant antiulcer activity in a dose dependent manner. The protection of ulcer may due to the presence of antioxidant principles present in the plant.

Keywords: Delonix regia, Antiulcer, Ethanol
WAFERS TECHNOLOGY – A NEWER APPROACAH TO SMART DRUG DILEVERY SYSTEM

WAFERS TECHNOLOGY – A NEWER APPROACAH TO SMART DRUG DILEVERY SYSTEM

Authors: Papola Vibhooti, Kothiyal Preeti
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Abstract

The lyophilized wafer developed throughout this review is an effective and versatile drug delivery system for oromucosal application. This has been established from the extensive physicochemical and physic mechanical profiling conducted. Through a screening and selection of polymers, HPC had the lowest gelation characteristics and was therefore suitable for the development of the wafer system. Suitable excipient and polymer combinations were established which allowed for the development of rapidly disintegrating and prolonged release wafer systems. The wafer system containing HPC, lactose, mannitol and glycine had the ability to disintegrate within 30 seconds. The modified wafer system, consisting of pectin cross linked with zinc ions serving as the drug reservoir, and mucoadhesive polymer combination of pectin, carmellose and gelatin, provided effective release of model drug diphenhydramine hydrochloride over approximately six hours. The modification of this technology to provide a prolonged release mucoadhesive system seems promising. It is envisaged that this system will be applicable to many drugs requiring the extended release of bioactive material. Therefore, the lyophilized wafer matrices developed in this study are highly effective in the rapid delivery of drugs, using the oral route as a site of administration.

Keywords: Glioblastoma, glycospingolipids, acylceramides, matrices and lyophilized
PREPARATION, CHARACTERIZATION AND EVALUATION OF OLMESARTAN MEDOXOMIL-Β CYCLODEXTRIN COMPLEXES

PREPARATION, CHARACTERIZATION AND EVALUATION OF OLMESARTAN MEDOXOMIL-Β CYCLODEXTRIN COMPLEXES

Authors: V. Prudhvi Raj, Subhashis Debnath, T.Malleswari, B.Bhaskar Naik, M. Niranjan Babu
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Abstract

Olmesartan medoxomil is a poor water soluble drug. There are numerous approaches available and reported in literature to enhance the solubility of poor water soluble drugs among which cyclodextrin complexation is predominant. β-cyclodextrin was used since this possess a special ability to complex with drugs enabling them to increase solubility, reduce bitterness, enhance stability and decrease tissue irritation upon dosing. Olmesartan medoxomil-β cyclodextrin complexes were prepared and characterized by FT-IR and SEM, studies. The results showed the formation of true inclusion complexes at molar ratio 1:5. In contrast crystalline drug was detectable in all other products. The dissolution of Olmesartan medoxomil from all the prepared complexes has been carried out to determine the most appropriate ratio that can be used for further development like tablet formulation for oral delivery. The complexes prepared by physical mixture method in 1:5 ratio showed superior dissolution profile when compared to complexes prepared in other ratios. From this research work it can be concluded that β CD has potential to increase the solubility of Olmesartan medoxomil and true complexes are formed in 1:5 ratio and because of the higher dissolution profile it can be used for further formulations.

Keywords: β-cyclodextrin, complex, inclusion complexes, dissolution
SYNTHESIS AND CHARACTERIZATION OF 1, 3, 4-OXADIAZOLE AND 1,3,4- THIADIAZOLE

SYNTHESIS AND CHARACTERIZATION OF 1, 3, 4-OXADIAZOLE AND 1,3,4- THIADIAZOLE

Authors: Ramanji Naik
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Abstract

There are vast numbers of pharmacologically active heterocyclic compounds in regular clinical use. The presence of heterocyclic structures in diverse types of compounds is strongly indicative of the profound effects such structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The 1, 3, 4-oxadiazole and 1,3,4- thiadiazole nucleus has emerged as one of the potential pharmacophore responsible for diverse pharmacological properties. Literature is flooded with reports of a variety of biological activities of 2, 5-Disubstituted-1,3,4- oxadiazoles and 1,3,4- thiadiazole. The search for better anticonvulsant drug and the importance of 2,5- disubstituted 1,3,4-oxadiazoles and 1,3,4- thiadiazole as anticonvulsant pharmacophores, prompted us to design, synthesize and evaluate a series of differently substituted 1,3,4-oxadiazoles and 1,3,4- thiadiazole for their potential anticonvulsant activity by autodock software.

Keywords: 1, 3, 4-oxadiazole and 1, 3, 4- thiadiazole , synthesis
INVITRO ANTI-INFLAMMATORY ACTIVITY OF STRYCHNOS POTATORUM LINN SEED BY HRBC MEMBRANE STABILIZATION

INVITRO ANTI-INFLAMMATORY ACTIVITY OF STRYCHNOS POTATORUM LINN SEED BY HRBC MEMBRANE STABILIZATION

Authors: V.Vijayakumar Dr C.K.Hindumathy
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Abstract

In the present study, strychnos potatorum linn belonging to the family Loganiaceae (Strychnaceae) was studied. It is a folkloric medicinal plant used to treat antibacterial, antifungal, anti diabetic, antioxidant and anti-inflammatory. Since many flavonoids have remarkable anti-inflammatory activity the present work aims at evaluating the anti inflammatory activity of seeds strychnos potatorum linn by HRBC membrane stabilization method. The prevention of hypo tonicity induced HRBC membrane lysis was taken a measure of anti inflammatory activity. The anti-inflammatory activity of hydroalcholic extract was comparable to that of the standard drug Hydrocortisone. The percentage protection for the hydroalcholic extract and hydrocortisone were 100 at µg/ml. the hydroalcholic extract of strychnos potatorum linn seed has significant anti-inflammatory activity (54.95±0.74).

Keywords: Anti-inflammatory, strychnos potatorum linn, HRBC membrane stabilization, Hydroalcholic extract
A REVIEW ON MEDICINAL PLANTS HAVING ANTIOXIDANT POTENTIAL

A REVIEW ON MEDICINAL PLANTS HAVING ANTIOXIDANT POTENTIAL

Authors: S.K Sharma, Lalit Singh, Suruchi Singh
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Abstract

Natural compounds from plants and other life forms (bacteria, fungi, marine organisms) represent a major source of molecules with medicinal properties. Among them, antioxidant substances are of particular interest. The understanding of the central role that oxidative stress holds in the progression of disorders as varied as: cardiovascular diseases, degenerative conditions, rheumatic disorders, metabolic syndrome, and in aging, makes antioxidant capacity to a key-feature of modern, multipotent remedies. A lot of medicinal plants, traditionally used for thousands of years, are present in a group of herbal preparations of the Indian traditional health care system (Ayurveda) named Rasayana proposed for their interesting antioxidant activities.

Keywords: Antioxidant, Ayurveda, Rasayana, Oxidative stress
EFFECTIVE HYPOGLYCEMIC ACTION OF METFORMIN COMBINATIONS AGAINST DEXAMETHASONE INDUCED DIABETES MELLITUS IN RATS

EFFECTIVE HYPOGLYCEMIC ACTION OF METFORMIN COMBINATIONS AGAINST DEXAMETHASONE INDUCED DIABETES MELLITUS IN RATS

Authors: Mohanraghupathy S, Jayabharath N, Bhuvana tejaY, Hameera khanam B, Lavanya lahari B
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Abstract

Diabetes mellitus is a chronic metabolic disorder occurs due to the damage of β-cells of islets of Langerhans in pancreas. In general patients suffering for diabetes mellitus always use the medicines, apart from the medicines they take insulin also. In our study we did the preclinical experimental study of Metformin combinations on Albino Wistar rats such that which combination is effective for the patients who are using purposefully using the insulin. Our studies shown that Metformin + Glipizide shown the effective hypoglycemic results. For inducing diabetes mellitus we introduced Dexamethasone intraperitoneally as it is a steroidal anti-inflammatory agent and it is having hypoglycemic action as adverse effect.

Keywords: Diabetes mellitus, metformin, glimepiride, glipizide
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF CINNARIZINE BY SUPER DISINTEGRANTS ADDITION METHOD

FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF CINNARIZINE BY SUPER DISINTEGRANTS ADDITION METHOD

Authors: Praveen Khirwadkar Kamlesh Dashora Shyam Bihari Sharma
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Abstract

The aim of the present work is to study the Preformulation parameters for Cinnarizine orodipersible tablet. The objective of pre-formulation study is to generate information useful to the formulator in developing stable and bioavailable dosage form. Administration of conventional tablets of Cinnarizine has been reported to exhibit fluctuations in plasma drug levels, either in manifestation of side effects or reduction in drug concentration at the receptor sites. Conventional Cinnarizine tablets available in market are not suitable where quick onset of action is required. Besides, the conventional tablets also show poor patient compliance particularly by the geriatric and pediatric patients who experience difficulty in swallowing, and by those who are bed ridden or who are traveling and do not have an easy access of water. Usage of excipients like low-substituted hydroxypropyl cellulose, crospovidone helps for the faster disintegration and faster release of the drug from the dosage form. The Preformulation studies were carried out in terms of test for identification (physical appearance, melting point, and UV spectrophotometer), solubility profile, and determination of partition coefficient and quantitative estimation of drug. All the observations and results showed that the Cinnarizine could serve as suitable candidate for fast dissolving tablet that may improve the bioavailability.

Keywords: Preformulation study, Orodispersible tablet, Patient compliance, Super disintegrants

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