Journal of Herbal Drugs

Journal of Herbal Drugs

Basic info

  • Publisher: Islamic Azad University, Shahrekord Branch
  • Country of publisher: iran, islamic republic of
  • Date added to EuroPub: 2018/Feb/04

Subject and more

  • LCC Subject Category: Marketing, Agricultural Science, Biotechnology, Botany, Genetics, Plant Sciences, Medicine, Pharmacology, Toxicology
  • Publisher's keywords: Herbs, Cultivation or Agronomy, Breeding, Biotechnology, Marketing and Economy, Medicinal Plants, Genetic
  • Language of fulltext: english, persian
  • Full-text formats available: PDF

Publication charges

  • Article Processing Charges (APCs): No
  • Submission charges: No
  • Waiver policy for charges? No

Editorial information

Open access & licensing

  • Type of License: CC BY
  • License terms
  • Open Access Statement: Yes
  • Year open access content began: 2011
  • Does the author retain unrestricted copyright? False
  • Does the author retain publishing rights? False

Best practice polices

  • Permanent article identifier: DOI
  • Content digitally archived in: Nopolicy
  • Deposit policy registered in: None

This journal has '260' articles

Hepatoprotective Properties of Ethanol Seed Extract of Citrus paradisi Macfad (Grape Fruit) Against Paracetamol-Induced Hepatotoxicity in Wistar Rats

Hepatoprotective Properties of Ethanol Seed Extract of Citrus paradisi Macfad (Grape Fruit) Against Paracetamol-Induced Hepatotoxicity in Wistar Rats

Authors: Godswill J Udom; Omoniyi K Yemitan; Emem E Umoh; H. O. C Mbagwu; Ekemini E. Ukpe; Paul S. Thomas
( 21 downloads)
Abstract

Background & Aim:The human body has the liver as one of its largest organs. It serves as the major site for metabolism and excretion. Injury to the liver or impairment of its functions may complicate one’s health and therefore, constitutes one of the serious public health challenges. The ethanol seed extract of Citrus paradisi Macfad (CPE) was carried out to evaluate its protective usefulness on the liver against paracematol-induced liver injury. Experimental:Thirty adult male Wistar rats were randomly allotted to five groups (6/group) and orally-treated daily with 100 mg/kg body weight of silymarin (positive Control), 10 ml/kg body weight of distilled water (negative control) and CPE (200, 400 and 600 mg/kg) body weight, respectively for 7 days. On the eighth day, all groups were administered 2 g/kg body weight of paracetamol. 24 h thereafter, animals were sacrificed under diethyl ether anesthesia and blood samples were collected by cardiac puncture for biochemical and haematological investigations. Results:Compared to the negative control, extract (200 – 600 mg/kg) significantly (p<0.05) reduced the activities of ALP, ALT and AST dosedependently. Extract significantly (p<0.05) elevated all blood parameters except for neutrophil differentials. Recommended applications/industries:Grapefruit seed extract possesses hepatoprotective potential and can be used as an antidote against paracetamol-induced hepatotoxicity.

Keywords: Citrus paradisi  Hepatocytes  Paracetamol-induced Hepatotoxicity  Hepatoprotection
Antidepressant activity of methanol stem bark extract of Ficus platyphylla Del (Moraceae) in mice

Antidepressant activity of methanol stem bark extract of Ficus platyphylla Del (Moraceae) in mice

Authors: Shehu Aishatu; Ngbara Ummi; Magaji Muhammad Garba; Yau Jamilu; Ahmed Abubakar
( 18 downloads)
Abstract

Background & Aim: Depression is a heterogeneous mood disorder affecting both people in developing and developed countries. The drugs used in its management are associated with adverse effects and delayed response which compromises their therapeutic benefits. This makes it worthwhile to look for antidepressants plants with proven advantage and favourable benefit-to-risk ratio. Ficus platyphylla is used traditionally in West Africa for the management of mental illnesses. The aim of this study was to evaluate the antidepressant potential of the methanol stem bark extract of F. platyphylla. Experimental: Thin layer chromatographic finger prints of the extract were established. The oral median lethal dose of the extract was estimated using OECD 420 guidelines. Antidepressant activity of the extract at doses of 125-500 mg/kg was evaluated using tail suspension test (TST) and forced swim test (FST). The Effects of the extract on motor co-ordination deficit and locomotion were evaluated using beam walking assay (BWA) and open field test (OFT) respectively. Results: The chromatographic profile suggested the presence of steroids, tannins, flavonoids, alkaloids and saponins. The LD50 was found to be ≥2000 mg/kg orally. The extract significantly (p<0.01) and dose dependently (125, 250 and 500 mg/kg) decrease the duration immobility in the TST and FST. There is no significant increase in the number of lines crossed and on the number of foot slips in the OFT and BWA respectively. Recommended applications/industries: The methanol stem bark extract of F. platyphylla possesses antidepressant activity. The phytoconstituents found present in the plant assumed to be responsible for the activity can be characterized and isolated to serve as lead compounds in the treatment of depression.

Keywords: Ficus platyphylla  Antidepressants  Depression tail suspension test  Forced swim test
Comparison of Two Spectrophotometric Methods for Quantifying Total Hydroxycinnamic Acids in Coneflower (Echinacea purpurea) Preparations

Comparison of Two Spectrophotometric Methods for Quantifying Total Hydroxycinnamic Acids in Coneflower (Echinacea purpurea) Preparations

Authors: Hossein Mahdavi; Mohammad Reza Naderi; Mohammad Hossein Esmaeili
( 19 downloads)
Abstract

Background & Aim: Hydroxycinnamic acids are one of the most important bioactive substances of Echinacea drugs. These compounds possess immuno-enhancing activity and thus, total hydroxycinnamic acids are mostly used as the main criterion for quality control of Echinacea purpurea and its drugs. Hence, the quality control of Echinacea requires to developing the reliable methods which are simple and also have a suitable accuracy in measuring total hydroxycinnamic acids. The current study was performed in order to sets a simple method for quantifying total hydroxycinnamic acids of Echinacea and then, comparison of this method which named as the AlCl3 method with the method of European pharmacopoeia (EP). Experimental: Total hydroxycinnamic acids of 10 coneflower samples were determined using AlCl3 and EP methods and the amounts obtained by these two methods, were compared using statistical criterion. Results: Accuracy of AlCl3 method in measuring total hydroxycinnamic acids of Echinacea was not suitable, as the relative difference between amounts measured by this method and those measured by EP method was 50-130%. Comparison of this method with EP method indicated that performance of AlCl3 method for quantifying total hydroxycinnamic acids of Echinacea drugs was very poor and low value of willmott index of agreement (d= 0.53) and high value of relative error (RE= 0.83) were obtained. Recommended applications/industries: Due to non-selective reaction of Al(III) with hydroxycinnamic acids, the AlCl3 method is not suitable for measuring the total hydroxycinnamic acids of Echinacea and its preparations.

Keywords: Echinacea purpurea  European pharmacopoeia  Hydroxycinnamic acid  Quality control
Antibacterial, Antifungal Properties and Chemical Composition of Essential Oils of Satureja hortensis L. and Satureja khuzestanica Jamzad

Antibacterial, Antifungal Properties and Chemical Composition of Essential Oils of Satureja hortensis L. and Satureja khuzestanica Jamzad

Authors: Ahmad Reza Golparvar; Mohammad Mehdi Gheisari; Amin Hadipanah; Mojtaba Khorrami4
( 20 downloads)
Abstract

Background & Aim: The aim of this study was to investigate the antibacterial, antifungal properties and chemical composition screening of essential oils of Satureja khuzestanica Jamzad and Satureja hortensis L. Experimental: For determination of antibacterial and antifungal activity of these essential oils, Staphylococcus aureus and Candida albicans were targeted, respectively. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of each essential oil were determined individually. Also, chemical composition of essential oils was identified and characterized by gas chromatography armed by mass spectrometry (GC–MS). Results: The total of 22 and 21 compounds were identified in the essential oils of aerial parts of S. hortensis and S. khuzestanica, respectively. The major components of S. hortensis essence were carvacrol (56.36%), γ- terpinene (24.75%), p-cymene (5.81%) and the major constituents of S. khuzestanica essence was reported carvacrol (69.62%), γ-terpinene (9.25%) and p-cymene (8.36%). The obtained results showed the antibacterial and antifungal activity of both extracted essential oils against the tested pathogens. The MIC and MBC of S. hortensis and S. khuzistanica essential oils against S. aureus were determined 0.1 and 0.5 μl/ml, and 0.1 and 0.2 μl/ml against C. albicans, respectively. Recommended applications/industries: The results showed that S.hortensis oil had higher antimicrobial activity compare to S. khuzistanica.

Keywords: Satureja khuzestanica Jamzad  Satureja hortensis L.  Chemical constitutes  Antimicrobial activity  Essential oils
Antimicrobial Effects of Zataria multiflora Essential Oils on Acinetobacter Strains Isolated from Clinical Specimens

Antimicrobial Effects of Zataria multiflora Essential Oils on Acinetobacter Strains Isolated from Clinical Specimens

Authors: Khadije Rezaie Keikhaie; Gholamreza Bagheri; Mehdi Hassanshahian; Saeide Saeidi
( 19 downloads)
Abstract

Background & Aim: The aim of this study was to investigate the antimicrobial effects of Zataria multiflora against some Acinetobacter baumannii strains isolated from clinical samples. Experimental: Twelve strains of Acinetobacter baumannii were isolated from referred patients in Zabol hospital. Essential oil of Zataria multiflora species was extracted using Clevenger device. Minimum Inhibitory Concentration (MIC) and Minimum Bacterial Concentration (MBC) of essential oil on mentioned bacteria were determined using micro dilution broth method at six different concentrations. Results: The results of this study showed that the lowest inhibitory concentration of essential oil against bacteria was 0.31 mg/ml, and only one strain of bacteria was inhibited. However, the highest inhibitory concentration was estimated 10 mg/ml. Recommended applications/industries: The results showed that the antimicrobial effects increased with increasing in essential oil concentration and the essence showed good antimicrobial activity even at low concentrations. With the use of essential oil of Zataria multiflora against bacterial pathogens, a good antimicrobial agent can be obtained without any side effects.

Keywords: Zataria multiflora  Essential oil  Antimicrobial activity  Acinetobacter baumannii  Minimum inhibitory concentration  Minimum bacterial concentration

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