Effects of aqueous crude leaf extract of senecio biafrae on the histology of the frontal cortex, kidney, liver and testis of male sprague dawley rats

Journal Title: Scientific Journal of Biological Sciences - Year 2012, Vol 1, Issue 1

Abstract

Whenever any plant and/or herb is ingested, the body system interacts with it in an attempt to get rid of any harmful toxins such may contain, especially if the body cannot convert the foreign substance into useful components. This study was to evaluate the effects of oral consumption of aqueous leaf extract of Senecio biafrae on the histology of the frontal cortex, kidney, liver and testis of Sprague Dawley rats as a marker of toxicity. Twenty adult male Sprague Dawley rats weighing between 100-158 g were used (4-6 weeks old). They were divided into 2 groups. The rats in the treatment group A received 300 mg/kg body weight of the aqueous leaf extract of S. biafrae for thirty days (30d). Histological observation of the frontal cortex, liver, kidney and testes revealed no significant abnormal alterations. The rats in the control group B received equal volume of phosphate buffered saline (PBS) also for 30d and no histopathological abnormalities were seen in the frontal cortex, kidney, liver, and testes of the rats. Aqueous leaf extract of S. biafrae has no deleterious effects on the histological profile of the frontal cortex, liver, kidney and testis of the rats.

Authors and Affiliations

A. O. Muhammed| Histopathology Unit, University of Ilorin Teaching Hospital, Ilorin, Nigeria, D. A. Adekomi*| Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria, and A. A. Tijani| Department of Anatomy, College of Health Sciences, Osun State University, Osogbo, Nigeria

Keywords

Related Articles

Histopathological study on the effects of oral administration of aqueous leaf extracts of cymbopogon citratus on the frontal cortex of male sprague dawley rats

This investigation was to evaluate the histopathological effects of oral consumption of the aqueous leaf extract of Cymbopogon citratus on the frontal cortex of Sprague Dawley (SD) rats. Ten male SD rats weighing between...

Antimicrobial effect of Satureja bachtiarica extracts aqueous and ethanolic on Escherichia coli and Staphylococcus aureus

In this study antimicrobial effect of extracts evaluated by two methods, “Collins method” and “disk agar diffusion method” on Escherichia coli PTCC 1330 and Staphylococcus aureus PTCC 1337 microorganisms. The minimum inh...

Occurrence of deoxynivalenol in cereals and cereal based products: a short review

During recentdecades, the contamination of cereal grains with toxic metabolites of Fusariumspecies has been increasingly documented. Deoxynivalenol (DON) is one of themost common trichothecene toxins produced by F. grami...

Fermented Beer-based Bait Attracted Insects Taxa in Songculan Lagoon, Songculan, Dauis, Bohol, Philippines

Insects are thedominant group of animals that have elongated body with distinct head, thoraxand abdomen that are bilaterally symmetric. Their presences in the ecosystemare mutually benefited by plants for they serve as t...

Prevalence and associated risk factors for soil transmitted Helminth infections among Urban Dwellers, Amanuel Town, Northwest Ethiopia

Infection by soil transmitted helminthes has been increasingly recognized as an important public health problem in poor and developing countries. To initiate prevention and control measures for these neglected diseases,...

Download PDF file
  • EP ID EP1058
  • DOI -
  • Views 563
  • Downloads 45

How To Cite

A. O. Muhammed, D. A. Adekomi*, and A. A. Tijani (2012). Effects of aqueous crude leaf extract of senecio biafrae on the histology of the frontal cortex, kidney, liver and testis of male sprague dawley rats. Scientific Journal of Biological Sciences, 1(1), 13-18. https://europub.co.uk/articles/-A-1058