- Journal title: Scientific Journal of Medical Science
- Publisher: Sjournals
- Country of
publisher: iran, islamic republic of
- Date added to
Subject and more
- LCC Subject Category: Dentistry and Oral Surgery, Nursing, Pathology and Forensics, Pharmacology, Pharmacy, Physiology, Surgery, Toxicology
keywords: Parkinson's disease, Dopaminergic neurons, Neurodegeneration, Substantia nigra pars compacta, Gene, Mutation
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- Full-text formats available: PDF
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R. Bolaños-Jiménez*| Neuroscience and Biotechnology Laboratory, School of Medicine, Universidad Panamericana, México DF, México.,
C. Escamilla-Ocañas| Tisular Engineering and Regenerative Medicine Laboratory, University of Monterrey, San Pedro Garza García, NL, México.,
H. Martínez-Menchaca| Tisular Engineering and Regenerative Medicine Laboratory, University of Monterrey, San Pedro Garza García, NL, México.,
G. Rivera-Silva| Tisular Engineering and Regenerative Medicine Laboratory, University of Monterrey, San Pedro Garza García, NL, México.,
O.F. Chacon-Camacho| Department of Genetics-Research Unit, Institute of Ophthalmology “Conde de Valenciana” Mexico City, Mexico.,
J.D. Carrillo-Ruíz| Department of Neuroscience and Psychophysiology, Universidad Anahuac, Mexico City.Neurosurgery Clinic of Spasticity, Service Functional Neurosurgery and Radiosurgery Hospital General de México O.D.
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The loss of dopaminergicneurons in the substancia nigra pars compacta leads to the characteristicsymptoms of Parkinson's disease (PD), whose Lewy bodies is a pathologic signalmost always found. Various monogenic forms account for a minority of cases ofPD, but have provided crucial insight into disease mechanism. However,genetically faithful models have not been exposed to putative toxicants in amanner that is clearly relevant to human exposures, and most of studies haveused conventional genetically modified animals and convenient dosing paradigms.Better translation between preclinical, neuropathologic animal model and,clinical research would be important for future clinical trials.