Formulation and Dissolution Study of Valsartan Immediate Release Tablets
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2013, Vol 1, Issue 2
Abstract
In the present study, design of oral immediate release tablets of Valsartan by direct compression technique was carried out. The main aim and objective of the work is to formulate immediate release tablets using different direct compression vehicles (DCV’S) in different ratios. The main motive is to compare the dissolution profile of these formulations and conclude the best formulation which release drug at a faster rate. To determine the best fit dissolution profile for the dosage forms. Valsartan tablets were formulated by using microcrystalline cellulose (diluents), potato starch, acacia (binder) and magnesium stearate (lubricant). The granules were compressed into tablets and were subjected to dissolution studies. The dissolution profile of the formulation F2 was found to have better dissolution rate compared to others. The In-vitro dissolution studies of all the formulations were conducted and the results were obtained, it was concluded that formulation F2 was the best with fast release of drug compared to others.
Authors and Affiliations
B. Brahmaiah| Department of Pharmaceutics, Priyadarshini Institute of Pharmaceutical Education & Research (PIPER), 5th Mile, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur-522017, Andhra Pradesh, India., K. Sasikanth| Department of Pharmaceutics, Priyadarshini Institute of Pharmaceutical Education & Research (PIPER), 5th Mile, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur-522017, Andhra Pradesh, India., Sreekanth Nama| Department of Pharmaceutics, Priyadarshini Institute of Pharmaceutical Education & Research (PIPER), 5th Mile, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur-522017, Andhra Pradesh, India., P. Suresh| Department of Pharmaceutics, Priyadarshini Institute of Pharmaceutical Education & Research (PIPER), 5th Mile, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur-522017, Andhra Pradesh, India., Patan Adam Khan| Department of Pharmaceutics, Priyadarshini Institute of Pharmaceutical Education & Research (PIPER), 5th Mile, Pulladigunta, Kornepadu (V), Vatticherukuru (M), Guntur-522017, Andhra Pradesh, India.
Keywords
Related Articles
- EP ID EP13413
- DOI -
- Views 441
- Downloads 23
Preliminary study of the digestive effects of Chenopodium ambrosioides Linn. (Chenopodiaceae) leaves extracts in goats
The effects of the crude aqueous extract of Chenopodium ambrosioides leaves on food intake and digestibility were evaluated with twelve Sahelian goats weighing about 25 kg. Three experimental groups, each consisting of...
Evaluation of antibacterial activity of Commiphora myrrha against antibiotic resistant clinical pathogens
There are many plants used by tribunal people as an anti bacterial, among them myrrh is the one which is commonly used. Myrrh is an oleo gum resin obtained from the plant Commiphora myrrha belongs to the family Burcera...
Evaluation of standardization parameter of polyherbal digestive “churna"
The development in these traditional systems of medicine leads to maintain proper quality of the product. India is rich in its flora and fauna. These plants are being used for curing many diseases as such in raw conditio...
Establishment of social clubs as a potential tool to educate adolescents living in urban field practice area of Shri BM Patil Medical college, Bijapur
Introduction: Globally half of the new HIV/AIDS cases are among the age group of 15 to 24 years and the greatest hope for changing the course of epidemic lies with the same agegroup. Within this age group, adolescents...
In-vitro antimicrobial susceptibility testing of bacteria causing diarrhea in children at Khartoum State- Sudan
Background: Diarrhea remains a major public health problem in developing countries. The current study was design to assess the antimicrobial susceptibility testing of bacteria causing diarrhea in children those antibio...