Pre-Implantation Immunosuppression in the Pregnant Rat:A Possible Role of Seminal Fluid
Journal Title: Sultan Qaboos University Medical Journal - Year 1999, Vol 1, Issue 1
Abstract
Successful reproduction involves exposure of the female in significant antigenic challenge. These experiments were done to test the possibility/hypothesis that seminal fluid has an immunosuppressive role in the early stages cf pregnancy, which cculd pretect the conceptus from immonological attack. A highly inbred strain cf rat AO(RTI“) was used in this study. Eleven groups of animals were examined, one during the estrous phase of the ovarian cycle to provide base-line data, five during pseudopregnancy, designated as controls, and five groups during syngeneic pregnancy. Each group contained a minimum of six animals. For each animal, body weight and organ/tissue weightsocf the uterus, thymus, uterine and popliteal lymph nodes, were recorded together with total cell counts of the lympocid tissues and their proliferating cell counts. The material was collected during each of the first five days of pregnancy and pseudopregnancy. The present study supports an immunological suppression by seminal fluid during early pregnancy as shown by a significant sustained depresson of the proliferative lymphocyte response in the uterine regional lymph nodes.
Authors and Affiliations
Omar A. Habbal| Department of Human and Clinical Anatomy, College of Medicine, Sultan Qaboos University. P.O.Box 35, Al-Khod 123, Muscat, Sultanate of Oman, John M. McLean| School of Biological Sciences, University of Manchester, Manchester, U.K.
Keywords
Related Articles
- EP ID EP13590
- DOI -
- Views 545
- Downloads 22
Daytime Sleepiness Among Young Adult Omani Car Drivers.
Objectives: Sleepiness and fatigue play significant roles in exacerbating the occurrence of car crashes. However, there is a dearth of studies examining the prevalence of sleepiness while driving among Omanis. This study...
Adult Hepatoblastoma What do we know?
A Comparative Study of Perceived Stress among Female Medical and Non-Medical University Students in Dammam, Saudi Arabia
Te objective of this study was to investigate any differences between female undergraduate medical and non-medical students for: 1) prevalence and causes of perceived academic stress, and 2) changes in physical, menta...
Acute Idiopathic Pulmonary Haemorrhage in a 2 month old Infant Case report and review of the literature
Pulmonary haemorrhage is usually secondary to a systemic disease affecting the lung with or without other organ involvement. Idiopathic pulmonary haemorrhage is a diagnosis of exclusion; as described in the literature,...
Gender Difference in Relationship of Apnoea/Hypopnoea Index with Body Mass Index and Age in the Omani Population
Objectives: Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a disorder characterised by repetitive upper airway collapse during sleep in association with daytime sleepiness. It has an estimated prevalence of 2%...