Distribution of arylamine N-acetyltransferase 2 (NAT2) genotypes among Omanis
Journal Title: Sultan Qaboos University Medical Journal - Year 2003, Vol 5, Issue 1
Abstract
Objective: to determine the genotypes of arylamine N-acetyltransferase (NAT2) among 127 unrelated apparently healthy Omanis. Method: Identify the most common known polymorphisms of NAT*2 gene namely, G191A, C282T, C341T, C481T, G590A, A803G and G857A using PCR-RFLP analysis. Results: Eleven allele variants (3 alternative) and 30 different genotypes were determined. The commonest alleles were found to be NAT*5B, NAT2*6A and NAT*4 with corresponding frequencies of 0.362, 0.248 and 0.189 respectively. The overall frequency of rapid acetylator alleles was 0.25. Conclusion: A new allele variant containing G590A, C282T and T341C polymorphisms was found in one subject (was named NAT2*5J). The commonest genotypes were found to be 5B/5B, 5B/6A, 4/5B, 4/6A with frequencies 0.165, 0.157, 0.118, 0.110 and 0.079 respectively.
Authors and Affiliations
Musbah O. M. Tanira| Departments of Pharmacology, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman, Mehmet Simsek| Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman, Khalid Al Balushi| Departments of Pharmacology, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman, Khulood Al Lawatia| Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman, Hameedah Al Barawani| Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman, Riad A. Bayoumi| Departments of Biochemistry, College of Medicine & Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Sultanate of Oman
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