Abstract

Molecular basis of the heredity hair loss has shown different types of mutations in different types of genes which are responsible for it among which of the major types of mutations includes Novel mutation, Recurrent Mutation and Splice Site mutation in following four genes that includes LIPH Gene on the chromosome number 3q26.3, G-protein coupled receptor (LPAR6/P2RY5) Gene the chromosome number 13q14.2, Desmoglein-4 (DSG4) gene at the chromosome number 8p21, Desmocollin (DSC3) genes, having locus on the chromosome number 18q12. These genes are mainly responsible for the Autosomal Recessive Heredity Hypotrichosis. While this point also cannot be ignored that Hypotrichosis also occurs in Autosomal Dominant form and some other types of genes are also discovered to be responsible for it that includes the KRT74 gene, which is responsible for the keratin k74 protein synthesis. Such genes are being found to be expressing themselves in the Human being’s hair follicles. Sequencing analysis of the KRT74 revealed heterozygous mutation c.422T4G (p. Phe141Cys) along the gene of K71 Keratin Initiation Helix Initiation encoded by KRT71 gene. Keywords: BASIS, Gene, Desmoglein-4 and Desmocollin

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