ENHANCEMENT OF SOLUBILITY OF POORLY WATER SOLUBLE LOVASTATIN DRUG BY SOLID DISPERSION METHOD
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 2
Abstract
Solid dispersions are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drugs. By reducing drug particle size to the absolute minimum, and hence improving drug wettability, solubility increases hence bioavailability may be significantly improved. They are usually presented as amorphous products, mainly obtained by two major different methods, melting and solvent evaporation KeyWords: Hot melt extrusion, Hyperlipidemia, Povidone, Eudragit RL, Eudragit RS, polyethylene glycol (PEG), degree of porosity, Renex, Texafor AIP
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The present investigation was done on lorazepam orodispersible tablets using super disintegrants. The prepared powder blend for all formulations was found to be within limits. Tablets were compressed using rotary tablet...
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The purpose of this study was to investigate the knowledge of residents of Saudi Arabia on the antibiotic use and its storage. This was a cross-sectional study. A pre-validated questionnaire was self-administered after t...