Correlation of some Drugs of Abuse in Human Urine by EMIT and GC/MS Analysis
Journal Title: Universal Journal of Environmental Research and Technology - Year 2011, Vol 1, Issue 4
Abstract
Drug toxicology tests are most commonly performed on urine, since most drugs and their breakdown products are excreted in the urine at higher concentration. A total number of 449 inhabitant urine samples were collected from patients admitted to emergency hospital, Mansoura University (Nov 1999 to June 2005). These samples were analyzed by EMIT and GC / MS for benzodiazepine, barbiturate, opiate and cannabinoid. The aim of this work is to evaluate the usefulness of using urine immunoassay kits for detection of some drugs of abuse, and study the correlation between the results obtained by EMIT and GC / MS techniques. Results revealed that urine immunoassay kit is useful for rapid preliminary screening of abuse drug. GC / MS results confirm that 245 samples (54.56 %) are positive of the total number of samples. These positive samples by GC / MS were as follows; benzodiazepines; 159 (clonazepam, oxazepam, temazepam), barbiturates; 58 (thiobarbiturate, butabarbital, seconal) and opiates; 28 (methadone metabolite)). We conclude that GC / MS analysis must be done for accurate identification and confirmation of EMIT results. Also, GC / MS is recommended as the most suitable technique for obtaining optimum analytical results.
Authors and Affiliations
Raafat A. Mandour
Keywords
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