EFFECT OF METHANOLIC EXTRACT OF ADENANTHERA PAVONINA LINN ON DALTON'S ASCITIC LYMPHOMA

EFFECT OF METHANOLIC EXTRACT OF ADENANTHERA PAVONINA LINN ON DALTON'S ASCITIC LYMPHOMA

Journal

Subject and more

  • LCC Subject Category: Biotechnology, Pharmacy
  • Publisher's keywords: Dalton's ascitic lymphoma, Tumor volume, Percentage Increase in Life Span, antitumor activity
  • Language of fulltext: english
  • Full-text formats available: PDF

AUTHORS

    Arihara Siva Kumar G, Rajesh Kumar Javvadi1, Vinay Kumar K, Manohar Reddy E, Veera Reddy Y, Harshavardhan G, Akbar MD

EDITORIAL INFORMATION

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ABSTRACT

The present study was undertaken to examine anticancer activity of Adenanthera pavonina L stem bark extract on Dalton's ascitic lymphoma (DAL) in male Swiss albino mice. Tumour was induced in mice by intraperitoneal injection of DAL cells (1 x 1000000 cells / mouse). Methanol extract of Adenanthera pavonina L (MAP) was administrated to the mice at the dose of 125 and 250 mg/kg/day, p.o. The antitumor effect of the extract was evaluated by using In-vitro cytotoxic assay; Mean survival time (MST), Tumour volume (TV), Percentage Increase in Life Span (ILS), viable and non-viable tumour cells count. The findings of this study indicate that the MAP possesses significant antitumor activity.

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