AN ICE-CREAM TYPE PHARMACEUTICAL FORMULATION OF PIPERAZINE HYDRATE AND ITS EVALUATION

AN ICE-CREAM TYPE PHARMACEUTICAL FORMULATION OF PIPERAZINE HYDRATE AND ITS EVALUATION

Journal

Subject and more

  • LCC Subject Category: Biotechnology, Pharmacy
  • Publisher's keywords: Ice creams, In-vitro diffusion profile, helminthic infection, piperazine hydrate
  • Language of fulltext: english
  • Full-text formats available: PDF

AUTHORS

    M Komala, K Hima Bindu , P Shanmugapandiyan, P Veera Swamy, R Sivakumar,

EDITORIAL INFORMATION

FULL TEXT

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ABSTRACT

The main objective of this work is to develop an ice cream type pharmaceutical formulation of piperazine hydrate and a process for preparing the same to substitute for tablets and syrups. Ice cream type formulations have merits over conventional formulae in-terms of compliance, so it can be used as an improved pharmaceutical formula for children affected by helminthic infection. The in-vitro diffusion profile of the formulation was studied in pH 1.5 buffer (acidic medium) and in pH 7.8 buffer (alkaline medium) for 2 hours in each buffer medium. The release in acid medium was 23.5% maximum at the end of 2 hours. This showed that only negligible amount of drug was released in acid medium. The release in pH 7.8 buffer was found to be 80% at the first 15mins which showed an immediate on-setting action of the drug in the body system. The drug release is prolonged up to 2 hours and absorption of up to 95% of the drug within 2 hours in the intestinal tract is possible. The diffusion study results concluded that major portion of the drug was available for the body system to cure the infection of Ascariasis.

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