FORMULATION DEVELOPMENT AND EVALUATION OF LOPERAMIDE HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS

FORMULATION DEVELOPMENT AND EVALUATION OF LOPERAMIDE HYDROCHLORIDE ORALLY DISINTEGRATING TABLETS

Journal

Subject and more

  • LCC Subject Category: Biotechnology, Pharmacy
  • Publisher's keywords: Loperamide hydrochloride, orally disintegrating tablets, Aspartame
  • Language of fulltext: english
  • Full-text formats available: PDF

AUTHORS

    A Bharathi, K Mohan Guptha, Y Uma Jagannadha Rao

EDITORIAL INFORMATION

FULL TEXT

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ABSTRACT

There is an increasing demand for more patient compliant dosage form and a novel method is the development of orally disintegrating tablets which dissolve or disintegrates instantly on the patient tongue or buccal mucosa. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect and make it more cost effective. Loperamide hydrochloride is a drug of choice for diarrhoea. Loperamide hydrochloride has systemic bioavailability too low due to extensive hepatic first pass metabolism. Hence the main objective of the study was to formulate orally disintegrating tablets of Loperamide hydrochloride to achieve a better dissolution rate and further improving the bioavailability of the drug and to get relief from diarrhoea very quickly. Orally disintegrating tablets prepared by direct compression and using super disintegrant crosspovidone were prepared and evaluated for the pre- compression parameters such as bulk density, compressibility, angle of repose etc. The prepared batches of tablets were evaluated for hardness, weight variation, friability,drug content, disintegration time and in-vitro dissolution profile and found satisfactory. Among the 6 groups (f1, f2, f3, f4, f5, f6),formulation f4 emerged as the best formulation and showed rapid dissolution rate i.e. it releases 95% drug in 5 min.

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