FORMULATION, DEVELOPMENT, EVALUATION OF CALCITRIOL AND CLOBETASOL

Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1

Abstract

Psoriasis vulgaris is a common skin disorder characterized by focal formation of inflamed, raised plaques that constantly shed scales derived from excessive growth of skin epithelial cells. Prevalence of Psoriasis is 2-3 % in general population. Currently, Topical Corticosteroids remain a pivotal treatment due to their effective anti-inflammatory properties; however potential adverse effects associated with chronic application limit long-term continuous therapy. Vitamin D analogues provide another mechanism of action reducing lesions through effects on keratinocytes and on cytokine environment. A topical combination of corticosteroid & Vitamin D derivative appears to provide a balanced approach to psoriasis treatment. When Calcitriol is used in combination with topical steroids, some improvement in psoriasis treatment was observed. The main side effect of Calcitriol is skin irritation. Topical steroids Clobetasol used in conjunction with Calcitriol may lessen skin irritation. Combination reduces hazards associated with long term use of topical Corticosteroids (atrophy and rebound) as well as irritation associated with Calcipotriol. Various formulations of Calcitriol (0.0003%) and Clobetasol Propionate (0.05%) were taken for optimization in relation to ointment base, consistency, ointment stability, stability with antioxidant, stability with different preservatives, and effect of temperature of Calcitriol phase addition to bulk white petrolatum base of ointment. Observations of all formulations for physical characterization and drug release profile had shown that, all comply with the specifications of official pharmacopeias and or standard reference. It was observed that, formulation batch- F12 selected as optimized formulation of Ointment, as it fulfills all requirements of Topical ointment.

Authors and Affiliations

Pasupathi A, Palanisamy P, B Jaykar, R Margret Chandira, B S Venkateswarlu

Keywords

Related Articles

A new development and validated RP-HPLC method for the assay and related substances of Itraconazole in capsule dosage form

The present investigation reveals about a simple, economic, selective, precise and accurate reverse phase high performance liquid chromatography method for analysis of Itraconazole and Related Substances of Itraconazol...

ANTIBACTERIAL ACTIVITY OF ETHANOLIC EXTRACTS OF NYCTANTHES ARBORTRISTIS AND NERIUM OLEANDER

In the present study, an attempt was made to investigate the anti-bacterial activity of Nyctanthes arbortristis and Nerium oleander. The crude drug powder extracts of the leaves of the above plants were taken for the s...

Micropropagation of an important medicinal plant Catharanthus roseus by using coconut water instead of synthetic plant growth regulators

The present in vitro study was conducted for micropropagation of Catharanthus roseus by using coconut water. The coconut water was used in five different concentrations i.e T1 (3 %), T2 (6 %), T3 (9%), T4 (12 %) and T5...

Development and Validation of new RP-HPLC Method for Simultaneous Estimation of Drug Bupropion and Zonisamide in Tablet Dosage Form

A simple, economic, accurate and precise reverse phase high performance liquid chromatography method for analysis of Bupropion and Zonisamide was developed and validated according to ICH guidelines. The quantification...

PLANT SEEDS USED FOR ANTHELMINTIC ACTIVITY:A REVIEW

Parasitic infections are most widespread among humans. The present study deals with a review on plant seeds which have been scientifically evaluated for in-vitro anthelmintic activity for supporting their folklore use...

Download PDF file
  • EP ID EP33016
  • DOI -
  • Views 531
  • Downloads 0

How To Cite

Pasupathi A, Palanisamy P, B Jaykar, R Margret Chandira, B S Venkateswarlu (2013). FORMULATION, DEVELOPMENT, EVALUATION OF CALCITRIOL AND CLOBETASOL. Indian Journal of Research in Pharmacy and Biotechnology, 1(1), -. https://europub.co.uk/articles/-A-33016