FORMULATION AND EVALUATION OF DEXLANSOPRAZOLE DELAYED RELEASE CAPSULES

FORMULATION AND EVALUATION OF DEXLANSOPRAZOLE DELAYED RELEASE CAPSULES

Journal

Subject and more

  • LCC Subject Category: Biotechnology, Pharmacy
  • Publisher's keywords: Dexlansoprazole, HPMC P 55 S, Eudragit L 100 55, pH 6.8 Phosphate buffer, Sodium Lauryl Sulphate
  • Language of fulltext: english
  • Full-text formats available: PDF

AUTHORS

    Peer Basha Syed, Chakravarthi V,Venkateswarlu B,Koteswararao P, Farooq Ahmed

EDITORIAL INFORMATION

FULL TEXT

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ABSTRACT

The present research work is formulation and evaluation of dexlansoprazole delayed release capsules. Dexlansoprazole is proton pump inhibitor (PPI) used in treatment of gastro esophageal reflux disease (G.E.R.D), Erosive esophagitis (E.E) and acid – related factors. In this research work various polymers like HPMC P55 S, Eudragit L 100 were used as enteric coating polymers were prepared in a fluidized bed coater (FBC). The pre-formulation studies such as solubility and compatability studies were carried out. In the formulation study of dexlansoprazole different formulation (F1 - F10) have been formulated and evaluated for acid resisitance, dissolution profile and release kinetics. The drug percentage release is more when compared with the marketed product. Stability study was done at various storage conditions and months for description, assay, water content, related substances. Mainly research work is to develop a pharmaceutically equivalent low cost quality improved and stable formulation and evaluation of dexlansoprazole delayed release capsules comparable to innovator product.

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