RECENT TRENDS IN POSITIVE AND NEGATIVE ASPECTS OF FOOD ON BIOAVALABILTY OF DRUGS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
The therapeutic effectiveness of a drug depends upon the ability of the dosage form to deliver the medicament to its site of action at a rate & amount sufficient to produce the desired pharmacologic response. This attribute of the dosage form is referred to as Physiologic availability or Biologic availability or simply availability. For most of the drugs, the pharmacologic response is directly related to the plasma levels. Thus, the term, Bioavailability is defined as the rate & extent (amount) of absorption of unchanged drug from its dosage form. Bioavailability refers to the difference between the amounts of a substance, such as a drug, herb, or chemical, to which a person is exposed and the actual dose of the substance the body receives. Bioavailability accounts for the difference between exposure and dose. A drug's therapeutic action or a chemical's toxicity is determined by the dose received at the target site in the body. The dose at the target site is determined by the amount of the substance absorbed by the body, which depends on its bioavailability. If a substance is ingested, for example, its bioavailability is determined by the amount that is absorbed by the intestinal tract. If a substance is inhaled, its bioavailability is determined by the amount that is absorbed by the lungs. Understanding bioavailability is critical to determining the amount of a drug to administer or the level of chemical exposure that is likely to produce toxicity.
Authors and Affiliations
Gowthami B Sk Nahida Fazilath Sanaulla Md K Prudhvi Raj Dastagiriah G Tabassum Sk
Keywords
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