L-arginine improves uterine spiral arterial wall thickness in mouse models of preeclampsia
Journal Title: Universa Medicina - Year 2017, Vol 36, Issue 2
Abstract
Background Preeclampsia is a major cause of maternal and fetal morbidity and mortality. The imbalance of anti-angiogenic and angiogenic factors plays a role in endothelial dysfunction in preeclampsia. L-arginine is expected to improve the process of spiral artery remodeling. This study aims to examine the use of L-arginine to repair endothelial damage by measuring the thickness of uterine spiral arteries in mouse (Mus musculus) models of preeclampsia. Methods The researchers carried out an experimental study using 30 sixteen-day old pregnant Swiss mice (in good health, weighing 20-25 grams), which were randomly divided into 3 groups (each consisting of 10 mice). The groups were as follows: 1) normal pregnancy K(-); 2) preeclampsia model K(+); and 3) preeclampsia model receiving L-arginine (P). The authors performed histopathological examination of the mouse placenta, which had been dissected, embedded in paraffin wax and subsequently stained with hematoxylin and eosin (HE). The results were analyzed in SPSS v. 21 for Windows using Anova with Tukey. Results The mean thickness of spiral arteries in group K(-) was 53.95 + 26.96 mm, in K(+) 96.50 + 16.66 mm, and in P 62.79 + 8.04 mm. Statistically, there were significant differences between groups K(-) and K(+) (p=0.001) and between K(+) and P (p=0.000), but non-significant differences between K(-) and P (p=1.000). Conclusions The treatment with L-arginine proved to be effective in repairing endothelial damage by reducing intimal hyperplasia an
Authors and Affiliations
Soetrisno Soetrisno, Sri Sulistyowati, Anwar Sandi Wibowo
Keywords
Related Articles
- EP ID EP376438
- DOI 10.18051/UnivMed.2017.v36.131-137
- Views 306
- Downloads 0
Membrane potential, serum calcium and serum selenium decrease in preeclampsia subjects in Owerri
Background Pre-eclampsia is a serious hypertensive condition of pregnancy associated with high maternal and fetal morbidity and mortality. Women who have had pre-eclampsia have a greater risk of developing hypertension,...
Decreased adiponectin level in adults with central obesity and low 25-hydroxy vitamin D level
Background Vitamin D insufficiency is associated with obesity and central obesity, which is in turn associated with the accumulation of visceral fat. Visceral fat secretes adiponectin which has a role in the pathogenesis...
Underweight increases the risk of pulmonary tuberculosis in adult
Background Tuberculosis (TB) is a leading cause of morbidity and mortality, especially in middle- and low-income countries. The risk of developing TB may be related to nutritional status. Socioeconomic and behavioral fac...
Increase in neutrophil count after repeated exposure of Plasmodium berghei-infected mice to artemisinin
Background Leukocytes play an important role in the elimination of malaria infection. The leukocyte profile upon elimination of the malaria parasites that have been exposed to antimalarials and are subsequently capable o...
Shortening tends to increase aortic foam cell count and wall thickness in male Wistar rats
Background Shortening is widely used as raw material for bread and other foods. Hypercholesterolemia increases aortic arch foam cell formation and abdominal aortic wall thickness. This study aimed to determine the effect...