Fundamental aspects of cardiovascular regulation in predisposition to atrial fibrillation
Journal Title: Moldovan Medical Journal - Year 2018, Vol 61, Issue 4
Abstract
Background: Atrial fibrillation is the most common sustained arrhythmia in cardiology. The structural factors leading to atrial fibrillation are well known, but there should be also regarded the functional factors. In 2014, the Task Force published guidelines for atrial fibrillation describing the importance of the vegetative nervous system in creating predisposition to atrial fibrillation although it describes that the mechanism is not completely clear. Furthermore, it is important to understand this mechanism, regarding the increasing number of patients affected by atrial fibrillation without any structural heart diseases. The aim of this work is to understand the physiological background of the predisposition to the appearance and recurrence of atrial fibrillation regarding the role of neural regulatory systems of the heart, especially when no structural heart diseases are present. Therefore, the following is a fundamental analysis of the neural regulation of heart rhythm, including the vegetative nervous system at its medullar and central levels and also the cerebral cortex input in heart regulation. Conclusions: The predisposition to atrial fibrillation regarding the neural regulatory systems of the heart can be pinpointed to three key factors: 1. Central over-activity; 2. Sympathetic efferent overflow towards the heart in rest state; 3. Parasympathetic exhaustion and break-down of the parasymphatetic protective function.
Authors and Affiliations
Ludmila Sidorenko, Ivan Diaz-Ramirez, Victor Vovc, Gert Baumann
Keywords
Related Articles
- EP ID EP479469
- DOI 10.5281/zenodo.2222313
- Views 347
- Downloads 0
Traumeel S – bioregulatory approach in the treatment of inflammation
Background: In the treatment of inflammation, the action of widely used non-steroidal anti-inflammatory drugs (NSAIDs) is directed mainly to inhibit the synthesis of proinflammatory mediators, cell migration and prolifer...
B-cell lymphoma-2 receptor in human primary breast and its lymph node metastases: more than a surrogate marker
Background: Due to its anti-apoptotic and anti-proliferative contradictory functions, BCL2 role in breast carcinoma progression is not clearly understood. The purpose of this study was to highlight BCL2 expression during...
Methodology of computed tomography of maxillofacial and craniocerebral regions by means of vertical fixation of the examined objects
Background: The research aims at identifying new methodological approaches to the study of morphological patterns of prenatal development of the human upper jaw. Material and methods: A working model has been developed a...
Tuberculosis characteristics and risk factors in urban compared with rural patients
Material and methods: A retrospective selective, descriptive study of socioeconomic, epidemiological peculiarities, case-management, diagnosis and microbiological characteristics of 694 patients with tuberculosis registe...
Fetal and neonatal complications of diabetic pregnancy
Background: There is currently convincing clinical and experimental evidence that a hyperglycemic intrauterine environment is responsible not only for significant short-term outcomes in the fetus and newborn infant, but...