The Effects of Glutamine and N-Acetylcysteine on Experimental Colitis Induced by 2,4,6-Trinitrobenzene Sulphonic Acid in Rats
Journal Title: Turkish Journal of Colorectal Disease - Year 2019, Vol 29, Issue 2
Abstract
Aim: Various factors including free oxygen radicals were have been described in the pathogenesis of inflammatory bowel disease. The aim of this study was to investigate the effects of antioxidant N-acetylcysteine (NAC) and combined glutamine (Gln) on experimental colitis. Method: In order to achieve this, rats were randomized and administered intraperitoneal NAC or oral Gln + intraperitoneal NAC one day after experimental colitis model induced with trinitrobenzen sulphonic acid. After the treatment, the rats were sacrificed and colon damage was evaluated macroscopically and microscopically. Malonyldialdehyde level and superoxide dismutase activity were analyzed biochemically. Results: NAC and Gln + NAC groups showed macroscopically better results than the colitis group. Histopathologically, all treated groups provided significantly lower scores than the colitis group. Similarly, all treated groups provided better biochemical results than the colitis group. Conclusion: According to the results of the experiment, it was concluded that NAC had positive effects on experimental colitis model.
Authors and Affiliations
İsmail Cem Eray, Orçun Yalav, Kubilay Dalcı, Ahmet Rencüzoğulları, Ahmet Gökhan Sarıtaş, Ömer Alabaz, Şule Menziletoğlu Yıldız, Gülşah Seydaoğlu, Figen Doran
Keywords
Related Articles
- EP ID EP48017
- DOI 10.4274/tjcd.galenos.2019.47640
- Views 350
- Downloads 0
Intussusception Caused by an Appendiceal Mucocele: Case Report
Intussusception of the appendix in to the caecum caused by an appendiceal mucocele is a rarecondition. Acute appendicitis is the most common presentation is of the disease. Radiologic examination methods especially compu...
How Can We Manage the Therapeutic Approach of Acute Diverticulitis Regarding the Number of Attacks?
Aim: The risk of acute diverticulitis (AD) increases with each attack and the decision of therapeutic management is getting more complicated. We aimed to investigate the effective features of the number of attacks. Meth...
Laser Hemorrhoidoplasty of a Single Surgical Centre
Aim: The aim of our study was to assess the outcome of hemorrhoidal dearterialization, achieved by a dedicated laser energy device. Method: From February 2013 to December 2017, 441 patients with second- or third-degree...
25 Carcinoid Tumor Cases Incidentally Detected After 4642 Appendectomies
Aim: This study aimed to retrospectively investigate 25 cases of carcinoid tumors in 4642 pathological examinations of patients who admitted to our clinic with acute appendicitis in a period of 6 years. Method: 4642 app...
Determination of Nursing Practices Related to Drain Care
Aim: Drains are frequently used for both therapeutic and prophylactic purposes during surgical procedures. Nurses have important duties in the process from insertion to removal of drain. The aim of this study was to dete...