The Effects of Glutamine and N-Acetylcysteine on Experimental Colitis Induced by 2,4,6-Trinitrobenzene Sulphonic Acid in Rats

The Effects of Glutamine and N-Acetylcysteine on Experimental Colitis Induced by 2,4,6-Trinitrobenzene Sulphonic Acid in Rats


  • Journal title: Turkish Journal of Colorectal Disease
  • ISSN: 2536-4898 (print) 2536-4901 (online)
  • Publisher: Galenos Publishing House
  • Country of publisher: turkey
  • Date added to EuroPub: 2019/Aug/13

Subject and more

  • LCC Subject Category: Medicine, Surgery
  • Publisher's keywords: Experimental colitis, glutamine, N-acetylcysteine
  • Language of fulltext: english, turkish
  • Full-text formats available: PDF
  • Time From Submission to Publication: 5


    İsmail Cem Eray, Orçun Yalav, Kubilay Dalcı, Ahmet Rencüzoğulları, Ahmet Gökhan Sarıtaş, Ömer Alabaz, Şule Menziletoğlu Yıldız, Gülşah Seydaoğlu, Figen Doran


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Aim: Various factors including free oxygen radicals were have been described in the pathogenesis of inflammatory bowel disease. The aim of this study was to investigate the effects of antioxidant N-acetylcysteine (NAC) and combined glutamine (Gln) on experimental colitis. Method: In order to achieve this, rats were randomized and administered intraperitoneal NAC or oral Gln + intraperitoneal NAC one day after experimental colitis model induced with trinitrobenzen sulphonic acid. After the treatment, the rats were sacrificed and colon damage was evaluated macroscopically and microscopically. Malonyldialdehyde level and superoxide dismutase activity were analyzed biochemically. Results: NAC and Gln + NAC groups showed macroscopically better results than the colitis group. Histopathologically, all treated groups provided significantly lower scores than the colitis group. Similarly, all treated groups provided better biochemical results than the colitis group. Conclusion: According to the results of the experiment, it was concluded that NAC had positive effects on experimental colitis model.

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