Association of decreased C1q/tumor necrosis factorrelated protein-5 levels with metabolic and hormonal disturbance in polycystic ovary syndrome
Journal Title: Journal of the Turkish-German Gynecological Association - Year 2019, Vol 20, Issue 2
Abstract
Objective: C1q/tumor necrosis factor-related protein-5 (CTRP5) is a novel peptide hormone involved in the metabolism of energy regulation. Polycystic ovary syndrome (PCOS), which is a reproductive and metabolic disorder, is associated with insulin resistance. The aim of the current study was to compare circulating levels of CTRP5 in women with and without PCOS and to investigate possible associations between CTRP5 and metabolic-hormonal parameters. Material and Methods: The present cross-sectional study contained 80 women with PCOS and 80 age and body mass index-matched women without PCOS. Circulating levels of CTRP5 were calculated using an enzyme-linked immunosorbent assay. We also measured hormonal and metabolic parameters. Results: Patients with PCOS had lower levels of circulating CTRP5 compared with women without PCOS (6.90±2.64 vs 11.73±3.66 ng/mL, p<0.001). CTRP5 was negatively correlated with insulin resistance, free-androgen index, and body mass index in both the PCOS and control groups. Moreover, patients with PCOS who had insulin resistance showed lower circulating CTRP5 levels compared with those without insulin resistance. In both the control and PCOS groups, overweight subjects had lower circulating levels of CTRP5 compared with participants of normal weight. Logistic regression analyses indicated that subjects in the lowest tertile for CTRP5 level had higher risk for PCOS compared with those in the highest tertile of CTRP5. Conclusion: Decreased circulating levels of CTRP5 were associated with higher risk of PCOS, as well as having metabolic disturbance among women with PCOS.
Authors and Affiliations
Mehmet Çalan, Murat Alan, Pınar Alarslan, Gökçen Ünal Kocabaş, Giray Bozkaya, Ahmet Çağdaş Acara, Behnaz Aslanipour, Özge Fenercioğlu, Ahmet Murat Işıl, Aslı Güler
Keywords
Related Articles
- EP ID EP48636
- DOI 10.4274/jtgga.galenos.2018.2018.0027
- Views 289
- Downloads 0
Polycystic ovarian syndrome: Environmental/occupational, lifestyle factors; an overview
Polycystic ovary syndrome (PCOS) is a multifaceted disease of women with infertility that has diverse etiologic factors. Some women may have only a few PCOS-linked symptoms or mild symptoms, whereas others will have seve...
Postoperative pain management in obstetrics and gynecology
The efficiency and quality of postoperative pain management may be considered unsatisfactory in Europe, as well as in the United States. Notwithstanding our better understanding of the physiology of pain and the developm...
Unusual usage of the automated stapler in gynecologic oncology: method for diaphragmatic full thickness implant resection without entrance to pleural space
No summary
Tips and tricks for laparoscopic interval transabdominal cervical cerclage; a simplified technique
With the advance of laparoscopic surgery, several minimally invasive cervical cerclage techniques have been described and the outcomes of those have been promising. With this video article, we describe a simplified techn...
Herlyn-Werner-Wunderlich Syndrome; laparoscopic treatment of obstructing longitudinal vaginal septum in patients with hematocolpos - a different technique for virgin patients
We aimed to define a new laparoscopic treatment approach for patients with hematocolpos and obstructed hemi-vagina due to longitudinal obstructing vaginal septum. This technique is particularly useful for patients who de...