Dietary Supplementing with Resveratrol Improves Antioxidant Status in Hypercholestrolemic Rats
Journal Title: GMJ Medicine - Year 2018, Vol 2, Issue 1
Abstract
Background and purpose: Natural agents have been used for protection against damages. This study was conducted to evaluate the effects of dietary supplementing of resveratrol on antioxidant status improvement in hypercholestrolemic rats with Plasmodium berghei. Methods: Rats were divided into 6 groups including rats fed with basal diet (Control group), basal diet containing resveratrol 2.5 mg/kg (2.5 RES), basal diet containing 5.0 mg/kg of resveratrol (5.0 RES), basal diet containing 1% cholesterol + 0.5% cholic acid (Control HC), basal diet containing 2.5 mg/kg of resveratrol and 1% cholesterol + 0.5% cholic acid (2.5 RES-HC), basal diet containing resveratrol 5.0 mg/kg and 1% cholesterol + 0.5% cholic acid (5.0 RES-HC). The plasma levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), malondialdehyde (MDA), and low density lipoprotein (LDL) and expression levels of glutathione peroxidase (GPx), glutathione reductase (GR), paraoxonase-1 and sulfiredoxin-1 were assessed. Results: The plasma concentrations of cholesterol, triglycerides, LDL-C and malondialdehyde were significantly higher and level of HDL was significantly lower in hypercholesterolemic rats, but dietary supplementation with resveratrol significantly improved them (P<0.05). Hypercholesterolemic rats showed a decrease in GPx and GR and an increase in paraoxonase-1 and sulfiredoxin-1 compared to the healthy control (P<0.05), but applying resveratrol improved the adverse effects of hypercholesterolemia on mentioned parameters (P<0.05). Conclusion: Resveratrol can be used for treatment of patients with hypercholesterolemia.
Authors and Affiliations
Sedighe Yousefi, Faezeh Nemati Karimooy, Toktam Miyanbandi, Fatemeh Esmaeilpour
Keywords
Related Articles
- EP ID EP49362
- DOI -
- Views 402
- Downloads 0
Modulation of 6-gingerolin Antidepressant-like Effects: An Investigation of Serotonergic System in Mice Model
Background: It has been reported that ginger is involved in serotonergic system. It seems that ginger effect could be attributed to its active compound or gingerol. The present study was conducted to evaluate the effects...
Efficiency of Probiotic in Immobilized Rats Through Involvement of the Antioxidant and Anti-inflammatory Systems
Background: Immobilization is known as type of stress that influences antioxidant status and inflammation factors. On the other hand, probiotics could significantly improve antioxidant status and inflammatory response. T...
Oral Administration of Menthol Alleviate Adverse Effects of Polycystic Ovarian Syndrome in Blood Biochemical Parameters and Antioxidant Status in Wister Rats
Background: Polycystic ovarian syndrome (PCOS) has been related to dyslipidemia and suppression of antioxidant status. Howeverl, novel agents such as menthol can be an efficient strategy for alleviation of PCOS. This stu...
Welcome to GMJ Medicine; The Official Medical Journal of the International Center for Intelligent Research (GMJ Medical Press, LLC, Germany)
GMJ Medicine is a continuous open access, online, peer reviewed journal owned and published by GMJ Medical Press, LLC in Germany from September, 2017. GMJ Medicine dedicated to publish good quality of research work in al...
An Overview on Novel Antioxidant and Anti-cancer Properties of Lycopene: A Comprehensive Review
Lycopene, a non-provitamin A carotenoid, is the reason for redness in tomatoes and some other vegetables. Lycopene has also been known as one fat-soluble red pigment that is produced by plants and some microorganisms. No...