Beneficial Effects of Curcuminon on Rats with Polycystic Ovary Syndrome: Evaluation of the Gene Expression of GLUT4, Erα and Insulin Resistance

Journal Title: GMJ Medicine - Year 2018, Vol 2, Issue 1

Abstract

Background and purpose: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in the women and animals. Some common hormonal therapies are used to treat the PCOS condition. This study was conducted to evaluate the effects of curcumin on rats with PCOS by evaluation of the gene expression of the GLUT4 and Erα and insulin resistance. Methods: Following induction of PCOS, sixty Sprague–Dawley female rats were divided into four groups including: (1) Control group (2) Control PCOS (3 & 4) those treated with 100 and 200 mg/kg of curcumin respectively. Body weight, fasting blood glucose (FBG), fasting insulin serum (FIS), homeostasis model assessment of insulin resistance (HOMA-IR) and gene expression of GLUT4 and Erα were evaluated. Results: Induction of PCOS increased body weight, FBG, FIS, HOMA-IR and decreased gene expression of GLUT4 and Erα (P<0.05), but oral administration of curcumin could alleviate adverse effects of PCOS on the mentioned parameters (P<0.05). Conclusion: It can be concluded that curcumin alleviates adverse effects of PCOS. It can be recommended to use the curcumin for the treatment of patients with PCOS.

Authors and Affiliations

Mohamad Kazem Shahmoradi, Majid Askaripour, Soodeh Rajabi, Giga Dzigandzli

Keywords

Related Articles

Nano-Phytosome of Quercetin Could Protect Liver from Plasmodium Berghei in Mouse Model

Background and purpose: Malaria is one of most important diseases especially in tropical regions. Flavonoids are known to have beneficial properties that could be profitable. This study aimed to evaluate the effects o...

Efficiency of Probiotic in Immobilized Rats Through Involvement of the Antioxidant and Anti-inflammatory Systems

Background: Immobilization is known as type of stress that influences antioxidant status and inflammation factors. On the other hand, probiotics could significantly improve antioxidant status and inflammatory response. T...

Carvacrol and Voluntary Exercise Improved Molecular Profile in Hippocampus of Male Rats Nourished with High-Fat Diet

Background and purpose: High-fat diet (HFD) is one risk factor in some disorders and increases oxidative stress. The use of carvacrol and voluntary exercise can be profitable. This study was thus conducted to evaluate...

Dietary Supplementing with Resveratrol Improves Antioxidant Status in Hypercholestrolemic Rats

Background and purpose: Natural agents have been used for protection against damages. This study was conducted to evaluate the effects of dietary supplementing of resveratrol on antioxidant status improvement in hyper...

Modulation of 6-gingerolin Antidepressant-like Effects: An Investigation of Serotonergic System in Mice Model

Background: It has been reported that ginger is involved in serotonergic system. It seems that ginger effect could be attributed to its active compound or gingerol. The present study was conducted to evaluate the effects...

Download PDF file
  • EP ID EP49363
  • DOI -
  • Views 369
  • Downloads 0

How To Cite

Mohamad Kazem Shahmoradi, Majid Askaripour, Soodeh Rajabi, Giga Dzigandzli (2018). Beneficial Effects of Curcuminon on Rats with Polycystic Ovary Syndrome: Evaluation of the Gene Expression of GLUT4, Erα and Insulin Resistance. GMJ Medicine, 2(1), -. https://europub.co.uk/articles/-A-49363