The effects of treadmill exercise on oxidative stress in Mongolian gerbils with penicillin-induced epilepsy
Journal Title: Experimental Biomedical Research - Year 2018, Vol 1, Issue 1
Abstract
Aim: To evaluate the role of treadmill exercise on the oxidative stress in Mongolian gerbils with penicillin-induced epilepsy. Methods: This experimental study included 18 male Mongolian gerbils which were divided into three groups; sham-control group, penicillin group (500 units) and exercise + penicillin (500 units) group. Each animal group was composed of six Mongolian gerbils. The epileptiform activity was verified by electrocorticographic recordings. Results: The latency of the penicillin+exercise group was longer than the penicillin group, but this difference was not statistically significant. Following the penicillin administration, spike wave frequencies of epileptiform activity in the 10, 30, and 35 minutes were significantly lower in the penicillin+exercise group, compared with the penicillin group. There were generally significant decreases in the spike wave amplitude medians in the penicillin+exercise groups compared with the penicillin group in all time periods between 0 and 5 minutes. The serum superoxide dismutase, catalase and glutathione peroxidase levels increased in the penicillin+exercise group compared with those in the penicillin group. Conclusion: The results of present study indicate that regular exercise may contribute to the amelioration of epileptic activity by increasing the antioxidant effect.
Authors and Affiliations
Ayhan Cetinkaya, Serif Demir, Hayriye Orallar, Yildirim Kayacan, Ersin Beyazcicek
Effectiveness of balneotherapy in knee osteoarthritis
Aim: We aimed to investigate the effects of balneotherapy on knee osteoarthritis in present randomized controlled single blind clinical trial. Methods: Patients with knee osteoarthritis according to ACR criteria whom...
Our experience regarding withdraw blood from rats and preparation of platelet-rich plasma
Aim: Withdraw blood from rats is an important, but not easy, invasive procedure in experimental research on these animals. In addition, the preparation and standardization of platelet-rich plasma (PRP) is a more difficul...
Relationship of coronary collateral development with mean arterial pressure in patients with stable coronary artery disease
Aim: The prognostic value of blood pressure and the association between these parameters and cardiovascular conditions have been established in literature. In this study, we aimed to investigate the correlation between p...
Effects of magnesium sulphate on liver ischemia/reperfusion injury in a rat model
Aim: To investigate the protective efficacy of magnesium sulphate in a model of rat liver ischemia-reperfusion (I/R) injury. Method: 32 adult female Wistar-Albino rats (250 to 350 g) were used in this experimental stu...
Patients’ misperception regarding the difficulty of lumbar puncture
Aim: Lumbar puncture (LP) is a crucial method of diagnosis and treatment of neurological diseases. Despite its importance, the patients' refusal of the procedure leads to difficulties in diagnosis and treatment. One of t...