Hemophagocytic syndrome secondary to Plasmodium vivax infection - A prospective study of 11 cases
Journal Title: Asian Pacific Journal of Health Sciences - Year 2018, Vol 5, Issue 1
Abstract
Background: Hemophagocytic syndrome is a reactive disorder of the mononuclear phagocytic system. The association of pancytopenia in severe malaria due to Plasmodium vivax with hemophagocytic syndrome is extremely rare and very few cases are reported in the world literature. Aim: The study was undertaken to establish P. vivax infestation associated with hemophagocytosis in bone marrow as one of the causes of chronic pancytopenia/bicytopenia with fever and splenomegaly in endemic areas. Materials and Methods: Prospective study of 110 patients of different age groups presenting with chronic fever with pancytopenia or bicytopenia from January 2015 to November 2017 was carried out. 49 patients showed the presence of P. vivax trophozoites in bone marrow. Among these 11 patients showed the presence of hemophagocytosis in bone marrow fulfilling 6 out of 8 criteria of diagnosing hemophagocytic lymphohistiocytosis according to 2004 criteria. Results: The age of patients varied from 8 years to 54 years. 11 Cases showed the presence of P. vivax trophozoites with the presence of hemophagocytosis in bone marrow showing, hyperplastic marrow showing normoblastic and megaloblastic hyperplasia. Conclusion: Hemophagocytic syndrome in malaria should be suspected in all cases of chronic fever with pancytopenia or bicytopenia, splenomegaly. Bone marrow aspiration is recommended to confirm the diagnosis of P. vivax as one of the causes of the secondary hemophagocytic syndrome in malaria-endemic areas.
Authors and Affiliations
nupur rastogi
Comparative study on the onset time and duration of brachial plexus block with addition of potassium chloride to bupivacaine versus plain bupivacaine
Background: Peripheral nerve blockade remains a well accepted component of comprehensive anaesthetic care. The onset of brachial plexus block is slow because the anaesthetic is usually deposited at some distance from the...
Unconventional Biomarkers: Early ‘Snapshots’ of Cardiovascular risk in Young Overweight and Obese adults
Background:Atherosclerosis of the coronary arteries leads to a restriction in coronary blood flow. Multiple studies have demonstrated that total leukocyte, monocyte and neutrophil counts are significantly higher in CAD p...
Induction of labour by amniotomy combined IV with syntocinon and IV syntocinon alone
Introduction: Induction of labour is artificial initiation of uterine contractions after the period of viability, with the intention of accomplishing delivery prior to onset of spontaneous labor. Oxytocin is the commones...
Various discrepancies during development of tongue
The tongue has a rich nerve supply and can detect not only the usual sensation of touch, pressure, heat and cold but also the special sensation of taste. This well developed sensory capability may be considered as a pro...
Pulsatile Drug Delivery System: A Review
Pulsatile drug delivery systems have been a major field of research recently. It is the most interesting time-specific and site-specific system. This system is designed for chronopharmacotherapy which is based on circadi...