Ethanol leaves extract of Mangifera indica (L.) exhibits protective, antioxidative, and antidiabetic effects in rats
Journal Title: Asian Pacific Journal of Health Sciences - Year 2018, Vol 5, Issue 1
Abstract
Objective: Many orthodox drugs used for treatment of diabetes have shown reported deleterious side effects. This study investigates the effects of ethanol leaves extract ofMangiferaindica(L) on alloxan-induced diabetic rats as an attempt to investigate herbal remedy. Methods: Male Wistar rats treated for fifteen days with average weight of 150g were randomlyselected into seven groups; 1(controls, received normal saline),2 (Alloxan-induced diabetic rats, 400mg/kg.bw subcutaneously),3 (Diabetic rats treated with extract,100mg/kg.bw),4 ( Diabetic rats treated with glibenclamide,5mg/kg.bw),5 (Diabetic rats treated with combination of extract and glibenclamide),6 ( extract only),7 (glibenclamide only).Biochemical and anti-oxidant indices were determined with standardized methods. Results: Results from indices studied revealed that alloxan-induced diabetic rats showed significant(p<0.05) increases in fasting blood sugar concentrations, white blood cell counts, lymphocytes counts, platelets counts, serum total cholesterol, triglycerides, liver malondialdehyde levels and percentage DNA fragmentation with corresponding decreases in serum total protein concentrations,red blood cell counts,high density lipoprotein concentrations and liver superoxide dismutase and catalase activities. Howeverin diabetic rats treated with extract(Group 3),levels and activities of these markers werereversed significantly and comparativelywith the standard drug (Group 4). Conclusions: These findings indicatepossible anti-oxidative,anti-diabetic,hypoglycemic,hypolipidemic and hepatoprotective effects of the extract and or a synergistic interaction with the standard drug .
Authors and Affiliations
J. A Badmas
Predictors of Post traumatic growth among breast cancer patients in Nepal
Objective: The main objective of this study is to investigate the prevalence, correlates and predictors of posttraumatic growth among breast cancer patients in Nepal. Method: A cross-sectional descriptive design was used...
Study of Factors associated with anaemia in pregnant females belonging to rural Haryana
Anemia is the most common nutritional deficiency disorder found in about 56% of all women living in developing countries as per World Health Organization. It is the second most common cause in India and is responsible f...
Knowledge, attitudes and practices towards drunk driving as a risk factor for road traffic accidents among public bus drivers in Ndola, Zambia
Introduction: Road Traffic Accidents account for about 1.4 million deaths globally. Human error, alcohol abuse in particular by road users is the leading cause of traffic accidents. Road Traffic accidents in Zambia are r...
Unconventional Biomarkers: Early ‘Snapshots’ of Cardiovascular risk in Young Overweight and Obese adults
Background:Atherosclerosis of the coronary arteries leads to a restriction in coronary blood flow. Multiple studies have demonstrated that total leukocyte, monocyte and neutrophil counts are significantly higher in CAD p...
Study of Morphological Features of Carcinoma of Breast in Relation to ER/PR and Her2/neu Status
Introduction: A steep rise in breast cancer cases is anticipated over the coming years in India. Breast cancer in India, is the most common cancer among women in the urban areas and ranks second in the rural population....