Comparasion Between Mitotic Activity, Ki-67 Index and Platelet Volume Index as a Prognostic Marker in Gliablastomas
Journal Title: Ankara Üniversitesi Tıp Fakültesi Mecmuası - Year 2019, Vol 72, Issue 2
Abstract
Objectives: An elevated platelet count is considered an independent prediction of survey in glioblastoma and various other intracranial entities. Activity of the tumor microcirculation resulting in platelet activation and release of several cytokines and factors from activated platelets has been suggested to play an active role in neuro-inflammation. Ki-67 index and mitotic activity are markers which could be showed proliferation in the glial tumor. High Ki-67 expression and mitosis rate of high grade glial tumors have been more aggressive clinical progression, poor prognosis, more vascular invasion than low. Recently, Mean Platelet Volume (MPV) to platelet count (PLT) ratio has become a trend indicator to anticipate the outcome of a patient suffering from intracranial pathologies. The study aims to determine first time whether the comparison of the Volume Index (PVI) as an immune response marker with the Ki-67 and mitotic activity could be used as a prognostic factor in gliablastoma (WHO Grade IV). Materials and Methods: In the retrospective study, we studied 65 patients diagnosed with glioblastoma who had inclusion and exclusion criteria. The correlation between PVI, Ki-67 and mitotic activity was examined all cases after pathologically diagnosed, by the routine processes of the pathological preparates. PVI was calculated from pre-operative first complete blood count (CBC) and was defined as MPV value (fL)x100/PLT (per 1000). The Kolmogorov-Smirnov test and Spearman’s correlation coefficient was used in the analysis of the interrelationship. Results: The correlation between the PVI, Ki-67 and mitotic index was found to be leak statistically correlation. Conclusion: It was determined that PVI is decreased, Ki-67 immunoreactivity and mitotic index are increased. The PVI may be used as a prognostic, predictive factor for glioblastoma. Nevertheless, further studies concerning the prognosis of glioblastoma are needed to confirm this hypothesis.
Authors and Affiliations
Tolga Turan Dündar
Keywords
Related Articles
- EP ID EP671758
- DOI 10.4274/atfm.galenos.2019.93584
- Views 162
- Downloads 0
Case Report and Review of Literature: Patient with Malignant Pheochromocytoma
Pheochromocytomas are catecholamine-secreting neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla. At least 10 percent of pheochromocytomas are malignant. A diagnosis of malignant pheochromocyto...
Long-term Follow-up Results of Patients with Percutaneous Endoscopic Gastrostomy and Factors Affecting Survival
Objectives: Percutaneous endoscopic gastrostomy (PEG) is a minimally invasive procedure with well-known efficacy and safety that is frequently used in patients who cannot be fed orally. In the literature, studies investi...
Hemispheric Differences in Brain Diffusion Values in 3 Tesla MR
Objectives: The purpose of this study is to demonstrate the variability of the diffusion values in different anatomical regions of the brain. Materials and Methods: 3T diffusion MR images of 190 patients underwent brain...
The Relationship Between the Tender Point Ultrasound Shear Wave Elastography Velocities and the Symptoms and Quality of Life in Fibromyalgia Syndrome
Objectives: The primary objective of the study was to determine the potential tissue changes and ultrasound elastography flow rates at the sensitive points in patients with fibromyalgia syndrome and to obtain objective d...
Stereotactic Radiofrequency Deep Brain Lesioning in Treatment of Dystonia
Objectives: Movement disorders are neurologic diseases that affect speed, quality and feasibility of muscle contractions. Aim of this study is, to assess the surgical outcomes of radiofrequency lesioning through deep bra...