Are Plasma Neutrophil Gelatinase Associated Lipocalin Levels Diagnostic in Uncomplicated Urinary Tract Infections?
Journal Title: Ankara Üniversitesi Tıp Fakültesi Mecmuası - Year 2019, Vol 72, Issue 2
Abstract
Objectives: Acute uncomplicated lower urinary tract infections are among the most common causes for emergency department visits and empirical antibiotic prescriptions. The purpose of this study was to determine whether the serum levels of the neutrophil gelatinase associated lipocalin (NGAL) molecule were important in the diagnosis and follow-up of non-complicated lower urinary tract infections. Materials and Methods: This was a cross-sectional, prospective study conducted from September 15, 2013 to April 15, 2014 in an academic emergency department. Eighty patients were enrolled in the study group and 40 healthy subjects in the control group. The patients had acute uncomplicated lower urinary tract infections with pyuria detected in a complete urinary test. All of the patients had their leukocyte, neutrophil, C-reactive protein (CRP), erythrocyte sedimentation rate, and NGAL levels evaluated before and after the treatment, and correlation among these parameters were investigated. Results: In the study group, the plasma leukocyte, neutrophil, and CRP levels before the treatment were significantly higher compared to the aftertreatment period (p<0.001). There was no significant difference found between the before-treatment and after-treatment levels of serum NGAL (p=0.091). Conclusion: Measuring plasma leukocyte, neutrophil, and CRP levels can support the diagnosis for urinary tract infections. However, plasma NGAL levels are not useful parameters for diagnosing non-complicated lower urinary tract infections.
Authors and Affiliations
Behnan Gülünay, Onur Polat, Ahmet Burak Oğuz, Arda Demirkan, Merve Ekşioğlu, Müge Günalp
Keywords
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- DOI 10.4274/atfm.galenos.2019.25744
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