SURVIVAL AND PROGRESSION AFTER RADICAL NEPHRECTOMY IN A COHORT OF NON-METASTATIC RENAL CELL CARCINOMA TREATED WITH CURATIVE INTENT

Journal Title: Journal of Ayub Medical College Abbottabad - Year 2019, Vol 31, Issue 3

Abstract

Background: Radical nephrectomy (RN) is a standard treatment of cure for non-metastatic renal cell carcinoma (NMRCC). Long-term outcome data are limited for Pakistani population. Our aim was to assess the long-term outcomes of RCC treated with curative intent with radical nephrectomy (RN) and to study the 5 & 10years survival outcomes in patients with NMRCC who underwent radical nephrectomy. Methods: This is a retrospective review and analysis of the data between December 2006 and February 2017. We included all the adult patients (age ≥18 years) with NMRCC from both genders irrespective of their histologic subtypes who underwent radical nephrectomy (RN) with a curative intent. The data was analysed for overall survival and recurrence rates at 5- and 10-years using Kaplan-Meier survival analysis. Multivariate analysis was performed using Cox-regression to identify risk factors associated with poor overall outcome in terms of recurrence and mortality. Results: Three hundred and forty-four patients with 195 (55.5%) males and 149 (44.2%) females with a mean age of 53.5±14.1 years were monitored for a mean follow-up of 31.1±26.77 months (range: 3–132 months). Overall there were 46 (13.4%) deaths. Forty-nine 14.2%) cases had disease recurrence with 33 (9.5%) deaths from disease progression. The 5-year progression-free survival was 37% (95% CI: 49.04–72.76) with the median time to recurrence of 33 months (95% CI: 27.6–38.4) and the median overall survival was 103.7 months (95% CI: 95.7–111.7). The 5-year overall survival was 76.1% (95% CI: 75.2–77) while 10-year survival was 70.8%. There was a significant median survival difference for cases with and without recurrence (log-rank χ2: 117.5, p<0.001), T stage, Fuhrman’s grade, and early postoperative recurrence. Conclusion: Radical nephrectomy offers the best survival for non-metastatic renal cell carcinoma patients with excellent postoperative survival and progression-free profile. Although renal cell cancer presents in younger age group but the long-term survival after radical nephrectomy in Pakistani population is similar to the rest of the world.

Authors and Affiliations

Keywords

Related Articles

ANALGESIC EFFECT OF DIRECT BREASTFEEDING DURING BCG VACCINATION IN HEALTHY NEONATES

Background: Pain during painful procedures in neonates has far reaching consequences. In developed countries many non-pharmacological interventions are used for neonatal pain reduction. Breast feeding has been proved to...

ECTOPIC WARTHIN’S TUMOUR MASQUERADING AS INFECTED BRANCHIAL CYST

Salivary gland tumours are relatively uncommon but they present globally regardless of age. Most of these tumours are benign and involve the parotid gland. Though strictly confined to the parotid gland, Warthin’s tumours...

GASTRIC DUPLICATION CYST: A RARE CONGENITAL ANOMALY CAUSING GASTRIC OUTLET OBSTRUCTION

Gastrointestinal duplication cyst is a rare congenital anomaly with a reported incidence of 1 in 4500 live births. Any part of gastrointestinal tract from mouth to anus can be affected with this anomaly. Among gastrointe...

OUTCOME OF USE OF 1% SILVER NITRATE IN PATIENTS WITH LOW LYING PERIANAL FISTULA

Background: Anorectal fistula is a common illness which is seen among the middle-aged male patients. Various surgical procedures have been proposed and are associated with the recurrence of the fistula, repeated surgery...

ASSOCIATION OF HYPERTENSIVE RETINOPATHY WITH ANGIOGRAPHIC SEVERITY OF CORONARY ARTERY DISEASE DETERMINED BY SYNTAX SCORE

Background: Hypertension is a leading cause of morbidity among developing and developed countries. Hypertensive Retinopathy is a micro vascular complication of long standing hypertension while CAD is a macro vascular com...

Download PDF file
  • EP ID EP673552
  • DOI -
  • Views 195
  • Downloads 1

How To Cite

(2019). SURVIVAL AND PROGRESSION AFTER RADICAL NEPHRECTOMY IN A COHORT OF NON-METASTATIC RENAL CELL CARCINOMA TREATED WITH CURATIVE INTENT. Journal of Ayub Medical College Abbottabad, 31(3), 314-319. https://europub.co.uk/articles/-A-673552