Efficiency of Akkermansia muciniphila in type 2 diabetes and obesity
Journal Title: Journal of Current Biomedical Reports - Year 2020, Vol 1, Issue 1
Abstract
Akkermansia muciniphila is an anaerobic species of gut microbiome that has been proposed as a new functional microbiota with probiotic properties. Recent research has shown the amazing abilities of probiotic bacteria, A. muciniphila, which resides in most people's intestines. These bacteria affect the body if it increases or decreases abdominal fat. The presence of A. muciniphila has opened new ways for the use of this plentiful intestinal symbiont in next-generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is particularly effective in increasing mucosal thickness and enhancing bowel barrier function. As a result, host metabolic markers improve. The host functions that are disrupted in various diseases with a particular focus on metabolic disorders in animals and humans. A specific protein in the outer membrane of A. muciniphila called Amuc-110 could in the future be a strong candidate for drug production. As a result, we suggest that microbes and our microbiology or gut microbiome knowledge could be a new source for future treatments. The objectives of this review are to summarize the data available on the distribution of A. muciniphila gut in health and disease, to provide insights into the environment and its role in the creation of microbial networks at the mucosal interface, as well as to discuss recent research on its role in regulation.
Authors and Affiliations
Farzaneh Mohammadzadeh Rostami, Saman Shalibeik, Bahram Nasr Esfahani
Keywords
Related Articles
- EP ID EP688953
- DOI -
- Views 290
- Downloads 0
Effects of Black Cumin (Nigella sativa L.) on patients with cancer and tumor: A systematic Review
Experimental studies demonstrated a positive effect of administration of Nigella sativa L. (Back cumin) and its active chemical components on cancer and tumor through the antioxidant and anti-cancer activity. This study...
HIV/AIDS awareness and attitude among factory workers in Shiraz, Iran
HIV has been introduced as a causative agent for AIDS which is still considered as a major health problem for the country and a burden on the health care system. Raising awareness and knowledge plays a critical role in c...
Evaluation of the correlation between serum lipid characteristics of obese subjects and ADIPOQ gene rs266729 polymorphism in Chaharmahal and Bakhtiari Province of Iran
Obesity is a multifactorial disorder that is influenced by various factors such as behavior, diet, environment, metabolic and genetic. This disease is the result of an imbalance between energy absorption and expenditure....
The role of proteases in the invasion of SARS-CoV-2 virus into human host cells
The new coronavirus, which originally broke out in Wuhan, China, in December 2019, increase quickly around the world, causing a pandemic all over the world. The virus uses its spike protein to enter the human host cells....
Detecting of biofilm formation in the clinical isolates of Pseudomonas aeruginosa and Escherichia coli: an evaluation of different screening methods
Biofilm producer bacteria cause nosocomial, chronic, and recurrent human infections. It is hard to treat biofilm-embedded bacteria because they are more resistant to antimicrobials than planktonic bacteria. The present s...