Chlorpyrifos chronic toxicity in broilers and effect of vitamin C
Journal Title: Open Veterinary Journal - Year 2011, Vol 1, Issue 2
Abstract
An experiment was conducted to study chlorpyrifos chronic toxicity in broilers and the protective effect of vitamin C. Oral administration of 0.8 mg/kg body weight (bw) (1/50 LD50) chlorpyrifos (Radar®), produced mild diarrhea and gross lesions comprised of paleness, flaccid consistency and slightly enlargement of liver. Histopathologically, chlorpyrifos produced degenerative changes in various organs. Oral administration of 100 mg/kg bw vitamin C partially ameliorated the degenerative changes in kidney and heart. There was insignificant alteration in biochemical and haematological profiles. It is concluded that supplementation of vitamin C reduced the severity of lesions induced by chronic chlorpyrifos toxicity in broilers.
Authors and Affiliations
A. M. Kammon| Department of Poultry and Fish Diseases, Faculty of Veterinary Medicine, Al-Fateh University, Tripoli, Libya, R. S. Brar| Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana, India, S. Sodhi| Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana, India, H. S. Banga| Department of Veterinary Pathology, College of Veterinary Science, GADVASU, Ludhiana, India, J. Singh| Department of Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Canada, N. S. Nagra| Department of Livestock Production and Management, College of Veterinary Science, GADVASU, Ludhiana, India
Keywords
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