A comparative study of analgesic efficacy of intrathecal bupivacain(0.5) heavy with different doses of midazolam(1mg and 2mg) as adjuvant in patients undergoing elective lower limb surgeries
Journal Title: Medpulse International Journal of Anesthesiology - Year 2018, Vol 5, Issue 3
Abstract
Background: Discovery of spinal receptors like alpha 2 adrenergic, cholinergic, opioid, NMDA and gamma aminobutyricacid(GABA)and benzodiazepine receptors trigger the use of drugs like neostigmine, clonidine, opioids ketamine,midazolam for their synergistic effect with intrathecal local anesthetics. Methodology: It was a double blind, prospective, randomised case control study patients with ASA 1 and 2 was taken. Exclusion criteria were patients with cardiac problem, respiratory problem, coagulation disorders, mental disorders and contraindication to regional block. Day before surgery preanesthetic evaluation was carried and procedure was explain to each patient. 0.5 mg alprazolam and ranitidine 150 mg given bedtime the night before surgery patient is kept NPO overnight. Results: Duration of motor block in group 1 and group 2 was 3.20(hr)0.73 & 3.500.77 P value 0.226.Duration of sensory block in group 1 and group 2 was 4.08(hr)0.88 & 6.67 (hr) 1.29 p-value <0.001 significant.There is higher duration of pain free period with group 2. So we can say that intrathecal 2mg Midazo lam added to bupivacaine,duration of postoperative analgesia was significantly prolonged than 1 mg idazolam. Conclusion: Effect of intrathecal midazolam is dose dependent 2mg midazolam prolongs the action of bupivacaine with good sedation and no unwanted side effects.
Authors and Affiliations
Swetha H R
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