A modern understanding of the surfactant protein mutations role in the formation of interstitial lung diseases in newborns and infants

Journal Title: Здоров`я дитини - Year 2018, Vol 13, Issue 5

Abstract

The article presents a modern understanding of the components of the surfactant, the functions of non-serum proteins SP-A, SP-B, SP-C and SP-D. The history of the discovery of protein deficiencies SP-B, SP-C and ABCA3 is described. The authors had analyzed modern epidemiology, clinical and histological features of various deficiencies of surfactant proteins. Va­rious variants of SFTPC, SFTPB and ABCA3 mutations and their influence on the course, clinical manifestations and outcome of interstitial lung disease in children are demonstrated.

Authors and Affiliations

O. L. Logvinova, M. A. Gonchar

Keywords

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  • EP ID EP386054
  • DOI 10.22141/2224-0551.13.5.2018.141570
  • Views 56
  • Downloads 0

How To Cite

O. L. Logvinova, M. A. Gonchar (2018). A modern understanding of the surfactant protein mutations role in the formation of interstitial lung diseases in newborns and infants. Здоров`я дитини, 13(5), 516-523. https://europub.co.uk/articles/-A-386054