A NEW NEO-CLERODANE DITERPENOID FROM TEUCRIUM POLIUM LINN.
Journal Title: International Journal of Pharmacognosy - Year 2017, Vol 4, Issue 6
Abstract
Teucrium polium L. is a member of the Lamiaceae family and is represented in the Flora of Syria by two variety: Teucrium polium var. angusti folium and Teucrium polium var. mollissimum. Teucrium polium is a wild-growing flowering plant, found abundantly in Syria, and it is used traditional medicine for its diuretic, antipyretic, antispasmodic, tonic, anti-inflammatory, antihypertensive, anorexic, analgesic, antibacterial and antidiabetic effects. Several reports have demonstrated a wide range of beneficial biological and pharmacological activities of the phenylethanoid, phenylpropanoid, and flavonoide components, while the furano neo-clerodane diterpenoids present in germander have been implicated in the in vivo hepatotoxicity of this botanical. Phytochemical studies of this plant have been carried out. Aerial parts of the plant were extracted with petroleum ether at room temperature, and then extract with methanol in Soxhlet, and finally extract with aqueous methanol at room temperature successively. Fractionation of the methanol extract by column chromatography and purification by crystallization yielded three known flvonoides Cirsimartin 2, Cirsiliol 3, and Apigenin 4. The aqueous methanolic extract yielded one new neo-clerodane type diterpenoid, Syrapolin I 1 (3,12- diacetoxy - 4α,18α ; 15,16- diepoxy - 6 – oxo – neo – cleroda - 13 (16), 14- diene -7α, 20β- dihydroxy-19- hemiacetal). The structure of compounds was proposed on the basis of spectroscopic methods IR, MS, and 1-D (1H, 13C and DEPT) and 2-D (COSY, HETCOR, HMBC) NMR experiment, and comparison with closely related compounds.
Authors and Affiliations
M. W. M. Sadaka
Keywords
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