A REVIEW ON ADHESIONS AND THEIR PREVENTION
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 12
Abstract
Adhesion formation is a physiological consequence of peritoneal tissue repair. Surgical trauma of the peritoneal surfaces induces a sequence of events that effectuates wound healing, therefore can also ultimately leads to adhesion formation.[7]Surgery induces an inflammatory reaction that is characterized by migration of neutrophils, macrophages and other leucocytes to the site of the inflammation during the first 48 to 72hrs [8]. Chemoattractants ( IL- 8, MCP -1 ), cytokines ( TNF – alpha, IL-1 beta and IL-6 ), growth factors ( TGF-beta, IGF-1 and PDGF ) and reactive oxygen species produced and released by residant and invading inflammatory cells and subsequent damaged mesothelial cells are the key mediators of this inflammatory reaction [9,10]. The magnitude of the problem, however, has tended to be overlooked, largely due to a lack of awareness regarding the clinical significance and the true incidence of adhesions [11] The adoption of effective adhesion prevention strategies will help to minimise the risk of adhesions following abdominal surgery and reduce complications, surgical workload and ultimately healthcare costs. Prevention strategies should include the adherence to good surgical practice alongside safe and effective anti-adhesion adjuvants.
Authors and Affiliations
Manoj Sharma| School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior (MP)–474011, India., Rashmi Dahima| School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior (MP)–474011, India., Anil Kumar Gupta*| PhD. Research Scholar Bhagvant University, Ajmer, Rajasthan, India
Keywords
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