A Study on anti-Inflammatory activity of Thiazolo-Thiourea Sydnones in albino rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2015, Vol 4, Issue 2
Abstract
Sydnones are proved to be important members of the meso-ionic system and are studied extensively for their pharmacological activities. In the present study several newly synthesized sydnones have been investigated for their anti-inflammatory effect. In the present study experiments for both acute and chronic anti-inflammatory activity were carried out viz., Carrageenan induced rat paw edema inhibition test to study the acute anti-inflammatory activity and cotton pallet granuloma inhibition test to study the chronic anti-inflammatory activity. These meso-ionic compounds-sydnones have been shown to possess anti-inflammatory. Among the various substituted thiazolyl thiourea sydnones 10 compounds were tried initially employing Carrageenan induced rat paw edema inhibition test for picking up an agent with anti-inflammatory activity. Compounds 3, 6, 8 and 9 which have shown considerable acute anti-inflammatory activity
Authors and Affiliations
Dr Jagadeesh K
Keywords
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